RecruitingNCT06086366

Presynaptic Imaging in Major Depressive Episodes After COVID-19

Sponsor

Centre for Addiction and Mental Health

Enrollment

90 participants

Start Date

Aug 22, 2023

Study Type

OBSERVATIONAL

Conditions

Long COVID Major Depressive Disorder Major Depressive Episode

Summary

The goal of this observational study focuses on understanding and addressing a subset of persistent neuropsychiatric symptoms occurring within 3 months after mild to moderate COVID-19 infection (COVID-DNP). COVID-DNP encompasses major depressive episodes (MDE) with or without additional neuropsychiatric symptoms.

Eligibility

Min Age: 18 YearsMax Age: 75 Years

Exclusion Criteria19

Age 18 to 75.
Good general physical health with no active medical conditions based on self-report (except migraine or PASC).
Use of antidepressants in the previous month (6 weeks for fluoxetine).
Use of stimulant medication affecting dopamine release in the previous month
Use of antipsychotics in the previous month
History of neurological disease (except migraine, and PASC) based on self-report
Use of medications or herbal products or natural health products with central nervous system effects in past 2 weeks based on self-report
Presence of cigarette smoking in the past two months, based on self-report
Lifetime diagnosis of severe Substance or Alcohol Use Disorder, or diagnosis of mild to moderate Substance or Alcohol Use Disorder in the past two years, based on self-report and verified by the Research Version of Structured Clinical Interview for Diagnostic and Statistical Manual-5 (SCID-5-RV)
Use of recreational drugs, including marijuana, in the past two months, based on self-report and verified by the Research Version of Structured Clinical Interview for Diagnostic and Statistical Manual-5 (SCID-5-RV)
Positive urine drug or cotinine screen at any timepoint during the study
History of psychotic symptoms secondary to schizophrenia, schizophreniform, bipolar disorder, or brief psychotic disorder prior to COVID-19, based on self-report and verified by the Research Version of Structured Clinical Interview for Diagnostic and Statistical Manual-5 (SCID-5-RV)
Currently pregnant, based on self-report or positive pregnancy test at any timepoint during the study, in females (in our PET Centre females up to 65 years of age are given a urine pregnancy test prior to every PET scan)
Breastfeeding (for females)
Current disorders of coagulation, blood or ongoing use of anticoagulant medication, based on self-report
Claustrophobia, based on self-report
Weight over 400lbs and height over 7ft (requirements for fitting in the scanners and hospital gowns)
Presence of metal implant, object or electrical devices that are contraindicated for MRI, based on self-report
Severe allergic reaction to alcohol