Prevention of Recurrence and Metastasis of Colorectal Cancer by Comparing Huaier With Capecitabine Monotherapy

This study is comparing two oral treatments for stage II colorectal cancer after surgery: a standard chemotherapy drug called capecitabine versus a traditional Chinese herbal medicine called Huaier (Trametes robiniophila Murr.). Researchers want to see if Huaier is as effective as or better than chemotherapy at preventing cancer from returning. **You may be eligible if...** - You are 18 or older - You have been diagnosed with stage II colorectal cancer confirmed by pathology - You had a complete surgical removal of your tumor (R0 resection) within the last 12 weeks - You have not had any chemotherapy or radiation before or after surgery - Your physical condition is acceptable (ECOG 0–2) - Your doctor has determined you should receive oral chemotherapy after surgery **You may NOT be eligible if...** - Your tumor is in the low rectum (within 12 cm of the anus) - You have a history of another cancer - You are allergic to Huaier granules or capecitabine - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.