Anastomotic Leakage After Colorectal Surgery.
Risk Factors for Anastomotic Leakage After Colorectal Surgery.
Minia University
430 participants
Aug 25, 2025
OBSERVATIONAL
Conditions
Summary
Anastomotic leakage (AL) is a severe complication after colorectal surgery, with incidence rates of 2-30%. This prospective, single-center observational cohort study aims to identify and quantify independent risk factors for AL, determine its incidence and impact on outcomes, and develop a predictive model. Approximately 430 patients undergoing colorectal resection with anastomosis will be enrolled from August 2025 to August 2026. Risk factors will be assessed preoperatively, intraoperatively, and postoperatively. AL will be defined and graded per the International Study Group of Rectal Cancer (ISGRC) criteria.
Eligibility
Inclusion Criteria3
- Aged ≥18 years
- Undergoing elective or emergency colorectal resection with primary anastomosis (e.g., ileocolic, colocolic, colorectal, coloanal)
- Providing written informed consent
Exclusion Criteria5
- Colorectal resection without anastomosis (e.g., end stoma)
- Inflammatory bowel disease (Crohn's, ulcerative colitis)
- History of previous colorectal surgery involving anastomosis
- Pregnancy
- Unable to provide informed consent or comply with follow-up
Interventions
All eligible patients undergoing elective/emergency colorectal surgery with primary anastomosis (e.g., ileocolic, colocolic, colorectal, or coloanal)
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07144683