RecruitingNot ApplicableNCT06096675

CAPACITY (Cardiac Amyloidosis and Physical ACtivITY) Study

Pilot Study Evaluating Supervised Cardiac Rehabilitation in Patients With Cardiac Amyloidosis


Sponsor

Wake Forest University Health Sciences

Enrollment

50 participants

Start Date

Jan 22, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

Exercise training in patients with heart failure and preserved ejection fraction (HFpEF) has been associated with an improvement in cardiorespiratory fitness and quality of life.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

The CAPACITY study is testing whether a supervised cardiac rehabilitation and exercise program can improve the physical fitness, quality of life, and heart function of people with cardiac amyloidosis — a condition where abnormal protein deposits stiffen the heart, leading to heart failure. **You may be eligible if...** - You are over 18 years old - You have been diagnosed with cardiac amyloidosis - You have heart failure at NYHA Class I, II, or III (mild to moderate symptoms) - You are able to exercise - You are on stable treatment for your cardiac amyloidosis (or under surveillance) - Your life expectancy is at least 6 months - You can commit to attending supervised exercise sessions 3 times per week for 12 weeks **You may NOT be eligible if...** - You have NYHA Class IV heart failure (severe, with symptoms at rest) - You require home oxygen for lung disease - You have gait instability or a history of falls - You are unable to give informed consent or commit to the study schedule Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORAL• Cardiac Rehabilitation

Intervention group will have baseline 6-minute walk test and cardiopulmonary exercise test (CPET) testing followed by supervised cardiac rehabilitation program including planned 3 one hour sessions a week for a total of 12 weeks (planned 36 sessions). A post intervention 6-minute walk test and CPET test will be performed within 2 weeks of completion of the 12 week program.


Locations(1)

Sanger Heart and Vascular Institute

Charlotte, North Carolina, United States

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NCT06096675


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