LIver Transplantation for Non-Resectable Intrahepatic CholAngiocarcinoma (LIRICA)

This study — called LIRICA — is testing whether liver transplantation can be a life-saving option for certain patients with intrahepatic cholangiocarcinoma (a cancer that starts inside the liver's bile ducts) that cannot be removed with surgery and has responded well to chemotherapy. **You may be eligible if...** - You have a confirmed diagnosis of intrahepatic cholangiocarcinoma (bile duct cancer within the liver) - This is your first diagnosis, or the cancer came back after a successful prior surgery but has not spread outside the liver - Your cancer cannot be removed by surgery due to its location, size, or liver condition - There are no signs of cancer outside the liver (no distant metastases or major blood vessel involvement) - You have received at least 6 months of standard chemotherapy and the cancer is stable or shrinking - Your general health and body weight (BMI 18–30) are acceptable for transplantation - At least 6 months have passed since diagnosis before being considered for transplant listing **You may NOT be eligible if...** - The cancer has spread outside the liver or involves nearby structures - You have not responded to chemotherapy (cancer is growing) - You have significant other medical conditions that would make transplant unsafe - Your BMI is outside the acceptable range Talk to your doctor to see if this trial is right for you.