RecruitingEarly Phase 1NCT06098612

PET Imaging Evaluation of [11C]SY08

Sponsor

Massachusetts General Hospital

Enrollment

40 participants

Start Date

May 1, 2024

Study Type

INTERVENTIONAL

Conditions

Multiple System Atrophy Dementia With Lewy Bodies Parkinson's Disease

Summary

The overall goal of the proposed research is to evaluate the use of \[11C\]SY08 as a PET radiotracer for aggregated alpha synuclein (αS) in individuals with Parkinson's disease (PD), Multiple system atrophy (MSA), Dementia with Lewy Bodies (DLB) and healthy controls. The purpose of this study is to evaluate the use of \[11C\]SY08 as a PET radiotracer for αS fibrils in individuals with PD, MSA, DLB and healthy controls. The specific aims of the current study are: 1. To determine brain uptake, distribution, and kinetics of \[11C\]SY08 in healthy individuals. 2. To determine brain uptake, distribution, and kinetics of \[11C\]SY08 in patients with alpha synuclein aggregates in the brain, including PD, DLB and MSA. 3. To determine human dosimetry of \[11C\]SY08 in healthy individuals An intravenous bolus injection of \[11C\]SY08 will be administered per subject for brain PET imaging.

Eligibility

Min Age: 50 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is using a specialized brain scan (PET/MRI) with a new imaging agent called [11C]SY08 to see if it can detect clumps of a protein (alpha-synuclein) that build up in the brain in diseases like Parkinson's disease, multiple system atrophy (MSA), and Lewy body dementia (DLB). This could help doctors diagnose these conditions earlier and more accurately. **You may be eligible if...** - You are between 50 and 80 years old - You can read, speak, and understand English - You are willing to undergo one PET/MRI brain scan session - For Parkinson's disease patients: you have a confirmed PD diagnosis and stable medications for at least 30 days - For MSA or DLB patients: you have a confirmed diagnosis and a study partner who can answer questions about your daily functioning **You may NOT be eligible if...** - You have uncontrolled high blood pressure or high cholesterol - You have major psychiatric conditions - You cannot undergo MRI scanning (e.g., metal implants, severe claustrophobia) - You are not able to communicate in English Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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