Locally AblatiVe TherApy in OLigO-pRogressive SOlid TUmorS (VALOROUS)

This trial (VALOROUS) is studying whether targeted local treatments — such as radiation, ablation, or other focused therapies — can help people whose cancer has started growing in just a few spots even while they are on systemic treatment. It includes several cancer types including breast, gynecological, head and neck, and sarcoma. **You may be eligible if...** - You are 18 or older - You have a confirmed solid tumor (breast, gynecological, head and neck, sarcoma, or other) - You are currently on systemic therapy (e.g., chemotherapy or immunotherapy) and your overall disease is mostly stable - You have 5 or fewer spots of cancer that are newly growing or progressing - Those progressing spots can be safely targeted with local therapy (radiation or ablation) - You have had at least 1 prior line of systemic therapy with at least 3 months of benefit **You may NOT be eligible if...** - Your overall health prevents you from safely receiving local ablative therapy - You have had prior treatment side effects that rule out ablative treatment - You have cancer growing in the brain Talk to your doctor to see if this trial is right for you.