Weaning Protocol for High-flow Nasal Oxygen Therapy in Intensive Care

This trial is comparing two ways to wean patients off high-flow nasal oxygen (a method of delivering extra oxygen through the nose at high speeds) in the intensive care unit after acute respiratory failure, to find the safest and most effective weaning approach. **You may be eligible if...** - You are an adult admitted to the ICU with sudden, severe low blood oxygen (acute respiratory failure) - You have been on high-flow nasal oxygen for at least 24 hours - You are currently receiving high-flow oxygen at ≥50 L/min and ≥50% oxygen concentration - Your breathing and oxygen levels have been stable or improving for the past 6 hours **You may NOT be eligible if...** - You are also receiving non-invasive mechanical ventilation at the same time - You were recently taken off a breathing machine (within 7 days of extubation) - You have severe COPD (chronic obstructive pulmonary disease, Gold grade 3 or 4) - Your main cause of respiratory failure is heart-related fluid in the lungs - You have a severe, diffuse lung disease (like pulmonary fibrosis) - You are on long-term home oxygen or home non-invasive ventilation - You are pregnant or breastfeeding - You have a medical decision stating you should not be intubated Talk to your doctor to see if this trial is right for you.