Acute Hypoxemic Respiratory Failure Clinical Trials

19 recruiting

Acute Hypoxemic Respiratory Failure Trials at a Glance

20 actively recruiting trials for acute hypoxemic respiratory failure are listed on ClinicalTrialsFinder across 6 cities in 11 countries. The largest study group is Not Applicable with 15 trials, with the heaviest enrollment activity in Toronto, Orléans, and Barcelona. Lead sponsors running acute hypoxemic respiratory failure studies include Lorenzo delSorbo, Columbia University, and Centre for Medical Sciences.

Browse acute hypoxemic respiratory failure trials by phase

Treatments under study

About Acute Hypoxemic Respiratory Failure Clinical Trials

Looking for clinical trials for Acute Hypoxemic Respiratory Failure? There are currently 19 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Acute Hypoxemic Respiratory Failure trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Acute Hypoxemic Respiratory Failure clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 20 trials

Recruiting
Not Applicable

Optimizing Care in Critically Ill at UCHealth by Liberalizing the Target O2 in Mechanically-ventilated ICU Patients

Respiratory FailureHypoxiaAcute Hypoxemic Respiratory Failure+3 more
University of Colorado, Denver3,600 enrolled1 locationNCT06501118
Recruiting
Not Applicable

Non-invasive Ventilation Versus High Flow Oxygen

Pneumonia-associated Acute Hypoxemic Respiratory Failure
Niguarda Hospital128 enrolled1 locationNCT03758508
Recruiting
Not Applicable

Targeting prEssure-Muscle-index to Avoid Ventilatory Over-Assistance During Pressure Support Ventilation

Mechanical Ventilation ComplicationAcute Hypoxemic Respiratory Failure
Centre for Medical Sciences36 enrolled1 locationNCT06921655
Recruiting
Phase 2

Interleukin-6 Guided Treatment With Dexamethasone or Tocilizumab in Patients Hospitalized With Acute Respiratory Symptoms - a Feasibility Study

Acute Hypoxemic Respiratory Failure
Lorenzo delSorbo60 enrolled1 locationNCT07334379
Recruiting
Not Applicable

IntHyx : Intubation Strategies for Patients With Acute Hypoxemic Respiratory Failure

Acute Hypoxemic Respiratory Failure
University Hospital, Angers200 enrolled9 locationsNCT07189078
Recruiting
Not Applicable

PEEP-induced Effects on Respiratory dRivE and EFfort

Acute Hypoxemic Respiratory FailureARDS (Moderate or Severe)
Radboud University Medical Center20 enrolled1 locationNCT07203781
Recruiting
Phase 4

Efficacy of DEXamethasone in Patients With Acute Hypoxemic REspiratory Failure Caused by INfEctions

Acute Hypoxemic Respiratory Failure
Dr. Negrin University Hospital980 enrolled40 locationsNCT04545242
Recruiting
Not Applicable

Awake Prone Positioning in Spontaneous Breathing Patients With Acute Hypoxic Respiratory Failure Due to Pneumonia

Acute Hypoxemic Respiratory Failure
Universitätsklinikum Hamburg-Eppendorf342 enrolled1 locationNCT06931938
Recruiting

EndotyPIng PreHospitAl de Novo Acute hYpoxemic Respiratory Failure

Acute Hypoxemic Respiratory FailureAcute Respiratory Distress Syndrome
Evangelismos Hospital250 enrolled1 locationNCT05150483
Recruiting
Not Applicable

Weaning Protocol for High-flow Nasal Oxygen Therapy in Intensive Care

Acute Hypoxemic Respiratory FailureHigh-flow Nasal Oxygen Therapy
University Hospital, Tours370 enrolled11 locationsNCT06104956
Recruiting

Pressure Muscle Index and Threshold of Over-assistance During Pressure Support Ventilation

Acute Hypoxemic Respiratory Failure
Unity Health Toronto20 enrolled1 locationNCT06494085
Recruiting
Not Applicable

EIT-Guided Ventilator Settings in AHRF

Acute Respiratory Distress Syndrome (ARDS)Acute Hypoxemic Respiratory FailureMechanical Power
Mahidol University17 enrolled1 locationNCT06936618
Recruiting
Not Applicable

The Effects of Music Therapy on Adult Patients Requiring Mechanical Ventilation in the ICU

Acute Hypoxemic Respiratory FailureAcute Hypercapnic Respiratory FailureAcute Respiratory Distress Syndrome
Icahn School of Medicine at Mount Sinai178 enrolled3 locationsNCT03642002
Recruiting
Not Applicable

Pilot Physiological Evaluation of an Investigational Mask with Expiratory Washout.

Acute Hypoxemic Respiratory FailureAcute Hypercapnic Respiratory Failure
Fisher and Paykel Healthcare32 enrolled2 locationsNCT06007495
Recruiting
Not Applicable

Effects of Face Mask Continuous Positive Airway Pressure Vs. Noninvasive Ventilation Vs. High-flow Nasal Oxygen on Intubation-free Survival in Acute Hypoxemic Respiratory Failure: the TRIPOD Randomized Clinical Trial

Acute Hypoxemic Respiratory Failure
Southeast University, China1,300 enrolled1 locationNCT06795971
Recruiting
Not Applicable

Closed-Loop O2 Use During High Flow Oxygen Treatment of Critical Care Adult Patients (CLOUDHFOT)

Respiratory FailureAcute Hypoxemic Respiratory FailureAcute Hypercapnic Respiratory Failure+1 more
Başakşehir Çam & Sakura City Hospital50 enrolled2 locationsNCT06374589
Recruiting
Not Applicable

Early Switch from Controlled to Assisted Ventilation

Acute Hypoxemic Respiratory FailureMechanical Ventilation
Erasmus Medical Center20 enrolled1 locationNCT06438198
Recruiting
Not Applicable

ROX Index for the Timing of Intubation in Nasal High Flow

Acute Hypoxemic Respiratory Failure
Hospital Universitari Vall d'Hebron Research Institute630 enrolled12 locationsNCT04707729
Recruiting

Airway Closure During Extracorporeal Membrane Oxygenation: The AiCLOSE Study

Acute Hypoxemic Respiratory Failure
Lorenzo delSorbo299 enrolled1 locationNCT05196074
Recruiting
Not Applicable

Physiological Effects of Continuous Negative External Pressure for Acute Hypoxemic Respiratory Failure

Acute Hypoxemic Respiratory Failure
Columbia University20 enrolled1 locationNCT05675345