Contribution of Fast-ripples to the Improvement of the Neurosurgical Management of Drug-refractory Epilepsy
University Hospital, Toulouse
440 participants
Jan 19, 2024
INTERVENTIONAL
Conditions
Summary
The main aim of this study is to evaluate the contribution of fast-ripples (FR) information on the neurosurgery management of patients with drug-refractory epilepsy investigated by Stereo-ElectroEncephaloGraphy (SEEG), as measured by freedom from disabling seizures one-year post-surgery. 220 patients (for whom 4-6 usual clinical macro-electrodes will be replaced by hybrid micro-macro electrodes and for whom fast-ripples will be assessed) distributed over 5 centres and 220 control patients(who will undergo an SEEG with the usual electrodes and for whom fast-ripples will not be assessed) distributed over 6 centres. This is a controlled, non-randomized, parallel plan, prospective, multicentre exploratory study.
Eligibility
Inclusion Criteria3
- Patient suffering from drug-resistant focal epilepsy (DRFE), as defined by the International League Against Epilepsy, undergoing SEEG, the indication of which was selected during a multidisciplinary epilepsy meeting
- Patient who has given written informed consent to allow the study data collection procedures
- Patient covered by the French healthcare system.
Exclusion Criteria5
- Patients under juridical protection (authorship, curators or safeguarding of justice).
- Patient deprived of liberty by a judicial or administrative decision
- Patient with a cardiac defibrillator
- Thermocoagulation planned on one of the potential hybrid electrodes .
- Patient in exclusion period of another study.
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Interventions
It is a deep intracerebral electrode used in the pre-surgical diagnosis of certain drug-resistant epilepsies. It consists of micro- and macro-contacts and is designed for Stereo-ElectroEncephalography (SEEG) recording via the macro-contacts or micro-contacts and brief stimulation via the macro-contacts.
Standard electrodes used usually during the SEEG
Locations(11)
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NCT06105645