Immunoprofilling of Peripheral Blood Mononuclear Cells in Children With Attention Deficit/Hyperactivity Disorder
First Affiliated Hospital of Zhejiang University
100 participants
Dec 4, 2023
OBSERVATIONAL
Conditions
Summary
The goal of this observational study is to learn about The immune cell landscape of peripheral blood mononuclear cells in children with ADHD compared to typically developing controls. The main question it aims to answer are: 1.Testing the differences in immune cell subpopulations, protein expression and signaling pathways and cell subsets between two groups 2. Exploring the correlations between immune function in PBMC and resting-state brain functional networks in children with ADHD. Participants will be taken peripheral blood about 5 ml , cognitive assessment including Intelligence testing, Stroop color-word test and Trail making test, clinical interview and brain structural and functional MRI.
Eligibility
Inclusion Criteria1
- Clinical diagnosis of ADHD； Children with an IQ≥70； Both parents are Han； Agree to take venous blood with informed consent；
Exclusion Criteria1
- Schizophrenia, mood disorder, autism, mental retardation； Obvious physical and nervous system abnormalities；
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Interventions
Participants will be taken peripheral blood about 5 ml
Locations(1)
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NCT06109337