Immune System Clinical Trials

41 recruitingLast updated: June 18, 2026

There are 41 actively recruiting immune system clinical trials across 16 countries. Studies span Not Applicable, Phase 2, Phase 1. Top locations include Bethesda, Maryland, United States, Atlanta, Georgia, United States, Houston, Texas, United States. Updated daily from ClinicalTrials.gov.


Immune System Trials at a Glance

41 actively recruiting trials for immune system are listed on ClinicalTrialsFinder across 6 cities in 16 countries. The largest study group is Not Applicable with 12 trials, with the heaviest enrollment activity in Bethesda, Atlanta, and Houston. Lead sponsors running immune system studies include National Institute of Allergy and Infectious Diseases (NIAID), National Cancer Institute (NCI), and CRISPR Therapeutics AG.

Browse immune system trials by phase

Treatments under study

About Immune System Clinical Trials

Looking for clinical trials for Immune System? There are currently 6 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Immune System trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Immune System clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 41 trials

Recruiting

Natural History, Management, and Genetics of the Hyperimmunoglobulin E Recurrent Infection Syndrome (HIES)

PneumoniaInfectionsImmune System Diseases+2 more
National Institute of Allergy and Infectious Diseases (NIAID)600 enrolled1 locationNCT00006150
Recruiting
Not Applicable

Immune Profile Analysis and Biomarker Identification in Women With Repeated Implantation Failure or Unexplained Recurrent Spontaneous Miscarriage

Recurrent miscarriageImmune SystemRepeated Embryo Implantation Failure
Centre Hospitalier Universitaire, Amiens150 enrolled1 locationNCT05648136
Recruiting

Sex-differential Host-microbiome CVD Risk - A Longitudinal Cohort Approach

Immune SystemGut MicrobiomeTransgender+1 more
Charite University, Berlin, Germany200 enrolled1 locationNCT05334888
Recruiting
Phase 2

Allogeneic Hematopoietic Cell Transplantation for Peripheral T Cell Lymphoma

Lymphoproliferative DisordersImmune System DiseasesPeripheral T-cell Lymphomas
National Cancer Institute (NCI)330 enrolled2 locationsNCT03922724
Recruiting

Activation and Function of Eosinophils in Conditions With Blood or Tissue Eosinophilia

Immune System DiseasesEosinophiliaHelminthiasis+2 more
National Institute of Allergy and Infectious Diseases (NIAID)800 enrolled1 locationNCT00001406
Recruiting

A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)

Hodgkin LymphomaNon-Hodgkin LymphomaHematologic Malignancies+14 more
Center for International Blood and Marrow Transplant Research99,999 enrolled142 locationsNCT01351545
Recruiting
Phase 2

Thinking Zinc: a Study of Zinc Supplements on the Navajo Nation

Immune System DisorderDNA Damage
University of New Mexico100 enrolled1 locationNCT03908736
Recruiting
Phase 2

A Study of the Safety and Activity of Sparsentan for the Treatment of Patients With Immunoglobulin A Nephropathy

Kidney DiseasesImmune System DiseasesAutoimmune Diseases+3 more
University of Leicester24 enrolled6 locationsNCT04663204
Recruiting
Phase 2

A Study of Treatment of Inflammation Before Stem Cell Transplant in People With a Primary Immune Regulatory Disorder (PIRD) and/or an Autoinflammatory Condition

Immune System DiseasesPrimary Immune Regulatory DisorderAutoimmune Lymphoproliferative
Joseph Oved39 enrolled13 locationsNCT05787574
Recruiting
Phase 2

Pilot Trial of Allogeneic Blood or Marrow Transplantation for Primary Immunodeficiencies

Lymphoproliferative DisordersImmune System DiseasesCommon Variable Immunodeficiency+2 more
National Cancer Institute (NCI)354 enrolled2 locationsNCT02579967
Recruiting
Phase 2

Improving Vaccine Protection for Adults

Healthy AdultImmune System Responses and Trained Immunity After AS01 Administration
Singapore General Hospital40 enrolled1 locationNCT07527247
Recruiting
Phase 2

Allogeneic Hematopoietic Stem Cell Transplant for Patients With Inborn Errors of Immunity

Lymphoproliferative DisordersImmune System DiseasesCommon Variable Immunodeficiency+2 more
National Cancer Institute (NCI)66 enrolled1 locationNCT04339777
Recruiting
Not Applicable

Exploration of Adaptive Antitumoral Immune Cells Through Lymphapheresis in Cancer Patients : ALCYTA

CancerImmune System or Toxicities Suspected
Institut Curie300 enrolled2 locationsNCT05354765
Recruiting
Phase 1

A Study to Evaluate a Novel Gene Therapy in Patients With Relapsed and Refractory Multiple Myeloma

NeoplasmLymphoproliferative DisordersNeoplasms by Histologic Type+11 more
Kelonia Therapeutics, Inc.70 enrolled7 locationsNCT07075185
Recruiting

VRC 900: Evaluation of Tissue-Specific Immune Responses in Adults 18 Years of Age and Older

Immunity, MucosalImmune System ProcessesBlood Specimen Collection
National Institute of Allergy and Infectious Diseases (NIAID)500 enrolled1 locationNCT01132859
Recruiting

Collection of Immunology Specimens From Patients With Cancer or Blood Disorders, and Healthy Volunteers

Hematopoietic and Lymphoid Cell NeoplasmMalignant NeoplasmHealthy Subject+2 more
University of Southern California625 enrolled1 locationNCT03207854
Recruiting
Phase 1Phase 2

A Study to Investigate Safety and Effectiveness of Porcine Pancreatic Cells (OPF-310) in Patients With Type 1 Diabetes Mellitus

Metabolic DiseaseDiabetes Mellitus, Type 1Type 1 Diabetes+14 more
Otsuka Pharmaceutical Factory, Inc.13 enrolled1 locationNCT06575426
Recruiting
Not Applicable

An Exploratory Study of Arginine Supplementation and the Postoperative Immune REsponse

SurgeryNutritional DeficiencyPreterm+1 more
University of Liverpool48 enrolled2 locationsNCT05306925
Recruiting

Montreal Immune-Related Adverse Events (MIRAE) Study

CancerAutoimmune DiseasesImmune System Disorder+1 more
Sir Mortimer B. Davis - Jewish General Hospital1,000 enrolled1 locationNCT05139706
Recruiting

Effects of Phytocannabinoids on Immune Response and Autophagy During Chronic Immune-mediated Inflammatory Diseases

Inflammatory Bowel DiseasesArthritis, RheumatoidSjogren's Syndrome+4 more
Centre Hospitalier Régional d'Orléans100 enrolled1 locationNCT06842316