GUIDE.MRD-01-CRC: Clinical Validation and Benchmarking of Top Performing CtDNA Diagnostics - Colorectal Cancer

This study validates and compares the best available blood tests for detecting circulating tumor DNA (ctDNA) — tiny fragments of cancer DNA shed into the bloodstream — in patients with stage III colorectal cancer or colorectal cancer that has spread to the liver. ctDNA tests may help detect cancer recurrence earlier than standard imaging. **You may be eligible if...** - You have stage III colorectal cancer and have undergone curative surgery and are a candidate for follow-up chemotherapy, OR - You have colorectal cancer that has spread to the liver and are planned for curative-intent treatment - You are able to understand and sign informed consent **You may NOT be eligible if...** - You have hereditary colorectal cancer conditions (familial polyposis or Lynch syndrome) - You have confirmed spread to distant organs (other than liver for the liver metastasis group) - You have had another cancer (other than colorectal or skin) in the last 3–5 years - Sufficient tumor tissue is not available for testing - You have liver cirrhosis (for the liver metastasis group) Talk to your doctor to see if this trial is right for you.