RecruitingNot ApplicableNCT06118931

Time-restricted Eating, Window Timing, Type 2 Diabetes Status and Sex on Glycemic Control

The Impact of Time-restricted Eating, Window Timing, Type 2 Diabetes Status and Sex on Glycemic Control

Sponsor

University of Toronto

Enrollment

120 participants

Start Date

Jun 28, 2025

Study Type

INTERVENTIONAL

Conditions

Obesity Diabetes Mellitus, Type 2 Hyperglycemia Prediabetic State

Summary

This study will evaluate the effectiveness of time-restricted eating (TRE), which is a form of intermittent fasting. When performing TRE, individuals consume all of their calories within a specific time window and then only consume water or other no calorie drinks the rest of the day. TRE is performed each day. There is no restriction on the quality or amount of food that people can consume during their eating window (ad libitum eating) with TRE, which can last anywhere from 4 to 12 hours. We are comparing three different 9-hour eating windows to determine whether the start and stop time of the eating window impact blood sugar control in individuals with obesity who also have or are at risk for type 2 diabetes. We also aim to determine if there are differences in the effects of the timing of eating window between males and females.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study looks at how limiting the hours you eat each day — called time-restricted eating — affects blood sugar control in people who have type 2 diabetes or are at risk of developing it. Researchers are also comparing whether the timing of the eating window (earlier or later in the day) makes a difference. **You may be eligible if...** - You are over 18 years old - Your body mass index (BMI) is between 30 and 50 - You have type 2 diabetes or score 33 or higher on the Canadian Diabetes Risk Score - You have access to a smartphone (Apple or Android) with Bluetooth **You may NOT be eligible if...** - You have had or are scheduled for weight-loss (bariatric) surgery - You have lost more than 5% of your body weight in the last 3 months - You are taking weight-loss medications - You weigh more than 340 pounds - You already eat within a window shorter than 12 hours on 5 or more days per week - You have a physician-diagnosed eating disorder - You have type 2 diabetes and are taking insulin, sulfonylureas, or more than 3 diabetes medications Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALEarly (7:00 - 16:00) TRE

A standardized TRE Protocol where participants eat ad libitum between the hours of 7:00 to 16:00 for 7 days. On the 8th day, they will consume a meal replacement beverage at 7:00, and not consume anything else for two hours.

BEHAVIORALMid (9:30 - 18:30) TRE

A standardized TRE Protocol where participants eat ad libitum between the hours of 9:30 to 18:30 for 7 days. On the 8th day, they will consume a meal replacement beverage at 9:30, and not consume anything else for two hours.

BEHAVIORALLate (12:00 - 21:00) TRE

A standardized TRE Protocol where participants eat ad libitum between the hours of 12:00 to 21:00 for 7 days. On the 8th day, they will consume a meal replacement beverage at 12:00, and not consume anything else for two hours.