SGLT2 Inhibitors in Patients With ADHF During Ventilator Weaning

This study tests whether a class of diabetes medications called SGLT2 inhibitors (such as empagliflozin or dapagliflozin) can help patients with severe heart failure who are on a breathing machine get off that machine more quickly and successfully. **You may be eligible if...** - You are 20 years or older - You are hospitalized for a flare-up of heart failure with a significantly reduced heart pumping function (ejection fraction of 40% or less) - You are currently on a breathing machine (ventilator) and are stable enough to begin weaning off it - Your blood pressure has been stable and you are no longer needing IV medications to increase your blood pressure or heart strength - Your heart failure markers in the blood are elevated **You may NOT be eligible if...** - You are in cardiogenic shock (your heart cannot pump enough blood) - Your heart failure was triggered by a heart attack or a blood clot in the lung - You had major heart surgery or a procedure within the past 30 days - You had a heart attack, stroke, or TIA in the last 90 days - Your kidneys are severely impaired - You have Type 1 diabetes or poorly controlled Type 2 diabetes - You have an uncontrolled urinary tract infection Talk to your doctor to see if this trial is right for you.