Contrast-Induced Acute Kidney Injury Prevention in Acute Heart Failure
Contrast-Induced Acute Kidney Injury in Acute Heart Failure With Renal Dysfunction: The Kidney Protection Strategies Evaluation in Acute Heart Failure (K-PROSE)
Jin Joo Park
190 participants
Jul 1, 2026
INTERVENTIONAL
Conditions
Summary
The K-PROSE study is a randomized clinical investigation evaluating strategies to prevent contrast-induced acute kidney injury (CI-AKI) in patients hospitalized with acute heart failure and moderate renal dysfunction (eGFR 30-75 mL/min/1.73 m²). Patients requiring contrast-enhanced CT imaging are randomized to either standard intravenous saline hydration or a furosemide-based decongestion strategy. Renal function is assessed using serial measurements of creatinine and cystatin C, before and after contrast exposure. By comparing renal outcomes, congestion status, and safety profiles, this study aims to determine whether a decongestion-focused approach provides superior renal protection compared with conventional hydration in high-risk acute heart failure patients.
Eligibility
Plain Language Summary
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Interventions
Intravenous furosemide administered to promote diuresis as part of a decongestion-based renal protection strategy.
Intravenous isotonic saline administered as standard hydration for the prevention of contrast-induced acute kidney injury.
Locations(1)
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NCT07550790