RecruitingNCT06144476

Study of Inflammatory and Physiological Profiles of Healthy and Diseased Lung

Sponsor

Guy's and St Thomas' NHS Foundation Trust

Enrollment

230 participants

Start Date

Feb 8, 2024

Study Type

OBSERVATIONAL

Conditions

Asthma COPD Airway Disease

Summary

There are over 700,000 UK hospital admissions every year with lung disease symptoms. Two of the most common lung diseases contributing to these numbers are asthma and chronic obstructive pulmonary disease (COPD). The immunopathology of these diseases is not fully understood. Matched samples from the respiratory tract and circulation will be used to identify immune patterns throughout the respiratory system to elucidate the immunopathology of airway disease.

Eligibility

Min Age: 18 Years

Inclusion Criteria4

Participant is willing and able to give informed consent for participation in the study
Aged 18 years or above
Patient: known or suspected airway disease
Healthy volunteer: considered to be in good health with no significant comorbidity (immune disorder, cancer etc.)

Exclusion Criteria9

Known or suspected current pulmonary tuberculosis, HIV (human immunodeficiency virus), Hepatitis B Virus, Hepatitis C Virus.
Surgery within the preceding 6 weeks
Participants who are pregnant
History of psychiatric, medical, or surgical disorders that in the opinion of the chief investigator may interfere with sample collection, undergo a bronchoscopy, or may compromise study completion or data collection
Alcohol or recreational drug abuse
Diagnosis of immunodeficiency requiring treatment
Unable to provide written informed consent
Unable to read or write English
Be considered, in the opinion of the investigator, to be an unsuitable candidate for the study