RecruitingNot ApplicableNCT06152497

The Role of Histamine in Muscle Protein Synthesis Following Resistance Training

The Role of Histamine in Muscle Protein Synthesis Following Chronic Resistance Training


Sponsor

University Ghent

Enrollment

50 participants

Start Date

Sep 1, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

Blocking histamine H1/H2 receptors blunts chronic endurance training adaptations. The current study addresses the following research question: "What is the influence of histamine H1 signaling on training adaptations following ten weeks of resistance training in human skeletal muscle." Results from this study will yield more insights into the molecular mechanisms of adaptations to exercise training.


Eligibility

Sex: MALEMin Age: 18 YearsMax Age: 45 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called H1 blockade: Telfast: 180mg Fexofenadine, a drug called Placebo, and others for people with histamine. The study is currently recruiting participants at 1 location. People eligible for this study include men aged 18 Years to 45 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGPlacebo

Oral placebo

DRUGH1 blockade: Telfast: 180mg Fexofenadine

H1 blockade: oral blockade with 180mg Fexofenadine

BEHAVIORALResistance training

Resistance training: lower body exercise


Locations(1)

Department of movement and sports sciences, Ghent University, Belgium

Ghent, Oost-Vlaanderen, Belgium

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NCT06152497


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