Perioperative Dexmedetomidine on Postoperative Delirium in Patients With Brain Tumors

This study tests whether giving dexmedetomidine (a sedative and pain-reducing medication) around the time of surgery helps prevent postoperative delirium — a state of sudden confusion that is common after surgery in older patients. It is tested in elderly patients having major non-cardiac surgery. **You may be eligible if...** - You are 65 years or older - You are scheduled for major non-cardiac surgery requiring general anesthesia - You are at risk for postoperative delirium **You may NOT be eligible if...** - You have severe heart conditions (very slow heart rate, heart block, or low blood pressure) - You have serious liver or kidney disease affecting drug clearance - You are already taking sedative medications that interact with dexmedetomidine - You have a pre-existing dementia or altered mental state before surgery Talk to your doctor to see if this trial is right for you.