Auditory Functions in Patients With Multiple Sclerosis
Electrophysiological Studies of Auditory Functions and CSF Analyses in Patients With Multiple Sclerosis
University of Catania
30 participants
Oct 1, 2023
OBSERVATIONAL
Conditions
Summary
The study will analyze the auditory functions of patients with Multiple Sclerosis using auditory tests like pure tone auditory test, speech perception test, Auditory Brain Response (ABR) and Distortion Product Otoacustic Emission (DPOAE). CSF will be collected by lumbar puncture and analyzed looking for inflammatory markers. The results of DPOAE and CSF will be correlated to identify statistically significant correlation.
Eligibility
Inclusion Criteria5
- age \>18 and \<50,
- no history of hearing loss,
- no psychiatric condition
- no familial history of otosclerosis/deafness/genetic hearing loss
- patients with PD and/or MS.
Exclusion Criteria8
- Conductive hearing loss
- stroke \< 2 years
- cardiovascular disease non under control
- diabetes
- hypotensive disorders
- alcohol abuse
- recreational drug consumption
- epilepsy
Interventions
The patients will perform: Pure Tone Auditory test + Tympanometry and Stapedial Reflex * Speech Perception test * In case of tinnitus: tinnitus questionnaire and acuphenometry * DPOAEs * ABR
Cerebrospinal Fluid will be collected by lumbar puncture and analyzed
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06164483