Semaglutide for Post-Smoking Cessation Weight Management

Exclusion Criteria44

• Medical Exclusions
• Personal or first-degree relative(s) history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2).
• Acute pancreatitis within the past 6 months prior to screening.
• History or presence of chronic pancreatitis.
• Type 1 or type 2 Diabetes Mellitus (previously diagnosed or indicated by HbA1C ≥48 mmol/mol (6.5%) as measured by central laboratory at screening).
• End stage renal disease (ESRD, previously diagnosed or indicated by estimated glomerular filtration rate (eGFR) value of eGFR \< 15 ml/min/1.73 m2 as measured by central laboratory at screening).
• Any of the following: myocardial infarction, stroke, hospitalization for unstable angina or transient ischemic attack within the past 60 days prior to screening.
• Systolic blood pressure (SBP) \>159 mmHg and/or diastolic blood pressure (DBP) \>99 mmHg)
• History of malignant neoplasms within the past 5 years prior to screening. Basal and squamous cell skin cancer and any carcinoma in-situ are allowed.
• Severe gastrointestinal disease (i.e., severe gastroparesis).
• Known or suspected hypersensitivity to nicotine/nicotine patches; semaglutide, excipients, or related products.
• Women who are currently pregnant, or plan to become pregnant, or lactating, or of childbearing potential and are not using medically accepted forms of contraception.
• Have any illness or condition which in the opinion of the Principal Investigator and/or the Study Physician would preclude safe and/or successful completion of the study.
• Psychiatric / Substance Use Exclusions
• Psychoactive substance abuse or dependence (excluding nicotine dependence) within the past 3 months prior to screening (existing diagnosis or as determined by the structured interview).
• Urine drug test positive, before randomization, for any of the following substances:
• benzodiazepines
• cocaine
• opioids
• amphetamines
• methamphetamine
• buprenorphine
• barbiturates
• ,4-methylenedioxy-methamphetamine (MDMA)
• Tetrahydrocannabinol (THC)
• Psychotic or bipolar disorder, or mood disorder with psychotic features; or eating disorder (existing clinical diagnosis or as determined by the structured interview)
• Moderate to high risk for suicidality (as determined by the structured interview).
• Weight-Related Exclusions
• Previously undergone bariatric surgery
• Gained/lost ≥4.5 kg over the past 6 months (prior to screening)
• Currently enrolled in a behavioral weight management plan
• Uncontrolled thyroid disease (the criterion will be assessed at the Study Physician's and the Principal Investigator's discretion)
• Smoking-Related Exclusions
• Currently using other combustible (e.g., cigars), other (e.g., chewing tobacco, snuff, snus) or alternative (e.g., electronic cigarettes) tobacco products
• Medication-Related Exclusions
• Currently using oral or injectable glucose lowering medications
• Currently using pharmacotherapy for smoking cessation (NRT, varenicline, or bupropion)
• Currently or recently (last 90 days prior to screening) taking medication used for weight management (i.e., orlistat, lorcaserin,vi naltrexone-bupropion, liraglutide, phentermine, topiramate, benzphetamine, diethylpropion, phendimetrazine)
• Currently or recently (within the past 14 days prior to screening) taking medication(s) known to impact appetite and/or weight (i.e., corticosteroids, excluding inhaled)
• General Exclusions
• Current, anticipated, or pending enrollment in another research study during this trial that could potentially affect participant safety and/or the study data/design as determined by the Principal Investigator and/or Study Physician.
• Not planning to live in the area for the duration of this trial.
• Surgery scheduled for the duration of the trial, except for minor surgical procedures, in opinion of the Principal Investigator and/or the Study Physician.
• Unable to communicate (read, write, and speak) fluently in English.