Changes of Renal Resistive Index in Critically Ill Patients Undergoing Continuous Renal Replacement Therapy.
Changes of Renal Resistive Index in Critically Ill Patients Undergoing Continuous Renal Replacement Therapy - Observational Study.
Uniwersytecki Szpital Kliniczny w Opolu
50 participants
Dec 19, 2023
OBSERVATIONAL
Conditions
Summary
The aim of the study is to determine whether there is a correlation between changes in the renal resistive index and the restoration of kidney function in critically ill patients undergoing continuous renal replacement therapy.
Eligibility
Inclusion Criteria1
- All ICU patients undergoing CRRT due to AKI
Exclusion Criteria13
- age <18 years
- pregnancy
- history of chronic kidney disease in stage 4 or 5
- post-kidney transplant status
- mechanical circulatory support
- occurrence of one or more conditions preventing reliable RRI measurement in both kidneys:
- challenging technical conditions of ultrasound examination, hindering proper visualization of the kidney
- post-kidney injury in grade III and higher, according to AAST
- advanced parenchymal kidney pathology: atrophy, hypoplasia, cirrhosis, extensive ischemia (more than 2/3 of the parenchyma),
- kidney diseases preventing parenchyma identification: advanced cancer (stage above T1 according to TNM), certain forms of polycystic kidney disease
- inflammatory kidney diseases
- obstructive uropathy
- renal vascular pathologies: renal vein thrombosis, significant stenosis (>60%), and renal artery occlusion.
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Interventions
The kidneys are preliminarily visualized in a 2D projection, followed by identifying interlobar or arcuate vessels using color Doppler. Flow measurements in these vessels are performed using pulsed-wave Doppler. Renal Resistive Index is determined over three cardiac cycles (five in the case of atrial fibrillation) in two different arteries, each in a different kidney section. Subsequently, measurements from each artery are averaged. If possible, the examination should be conducted bilaterally. The investigators do not have access to previous measurements (each study is recorded on a separate card).
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06174610