Focal Ablation With Focal Cryotherapy or HIFU for the Treatment of Men With Localized Prostate Cancer

This trial is comparing two types of focal ablation therapy — cryotherapy (freezing the tumor) and HIFU (high-intensity focused ultrasound that heats and destroys the tumor) — for men with localized, low-to-intermediate risk prostate cancer, to evaluate which approach better destroys the tumor while preserving urinary and sexual function. **You may be eligible if...** - You are male, 18 or older, with confirmed localized prostate cancer (Grade Group 1, 2, or 3) - Your cancer is visible on MRI as a lesion (up to 3 lesions allowed for focal treatment) - Your cancer has not spread to lymph nodes or other parts of the body - You have a life expectancy of at least 5 years and good performance status - You have not had prior treatment for prostate cancer **You may NOT be eligible if...** - Your prostate cancer has spread to lymph nodes or distant sites - You have already received treatment for prostate cancer (surgery, radiation, hormones) - You have significant heart disease or conditions that make anesthesia unsafe - You have blood clotting problems that cannot be corrected Talk to your doctor to see if this trial is right for you.