RecruitingNCT06182722

Association of Peripheral Immune Cells With Antidepressant Treatment Response

Sponsor

Shanghai Mental Health Center

Enrollment

90 participants

Start Date

Mar 13, 2024

Study Type

OBSERVATIONAL

Conditions

Depressive Disorder Genetic Change

Summary

The purpose of this observational study is discovering potential biomarkers to predict antidepressant treatment response in patients with major depressive disorder (MDD) while comparing the transcriptomic changes between patients with MDD and healthy controls as well as before and after antidepressant treatment. Eligible patients will be assessed at Week 1, Week 2, Week 4 and Week 8 while healthy normal volunteers will only be evaluated at baseline. Assessments will include the following: an interview about mental and physical health, a physical examination including drawing of venous blood samples and several psychiatric rating scales.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study examines whether specific immune cells in the blood can predict how well someone will respond to antidepressant medications (SSRIs or SNRIs) for major depression. Research suggests the immune system may play a role in depression, and this study aims to identify biological markers that could eventually help doctors choose the most effective treatment for each person. **You may be eligible if...** - You are between 18 and 65 years old - You have been diagnosed with major depressive disorder (MDD) according to DSM-5 criteria - You are starting or currently taking an SSRI or SNRI antidepressant as a single medication - Your depression is moderate to severe (HAMD-17 score of 18 or above at the start) **You may NOT be eligible if...** - You have a different mental health diagnosis (e.g., bipolar disorder, schizophrenia) - You are taking multiple psychiatric medications - You have serious physical health conditions that affect the immune system - You are unable to provide informed consent Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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