Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes

This study is testing whether a combination of Cognitive Behavioral Therapy (CBT) — a structured form of talk therapy that targets negative thought patterns — and exercise training can improve depression and reduce Type 2 diabetes risk in teenage girls who are overweight and have a family history of diabetes. Both mental health and metabolic health are targeted together in this program. **You may be eligible if:** - You are a female between 12 and 17 years old - Your BMI is at or above the 85th percentile for your age and sex (overweight or obese range) - You have a parent, sibling, or grandparent with Type 2 diabetes - Your depression score on a standard screening scale is elevated (CES-D ≥ 21) **You may NOT be eligible if:** - You have been diagnosed with Type 1 or Type 2 diabetes, or a serious heart or kidney condition - You have certain mental health conditions that require different treatment (e.g., conduct disorder, OCD, psychosis, anorexia) - You are currently pregnant or breastfeeding - You are on weight-loss medications or have had bariatric surgery Talk to your doctor to see if this trial is right for you.