RecruitingNCT06194968
Treatment of Acute Ischemic StroKe With Intravenous UroKinase Real-world Research: a Multicenter, Prospective Study
Treatment of Acute Ischemic StroKe With Intravenous UroKinase Real-world Research: a Multicenter, Prospective Study (TASK-UK)
Sponsor
The First Affiliated Hospital of Zhengzhou University
Enrollment
1,800 participants
Start Date
Dec 30, 2023
Study Type
OBSERVATIONAL
Conditions
Summary
The purpose of this study is to to compare the safety and effectiveness of IV urokinase with IV alteplase in the treatment of AIS in patients up to 6 hours from symptom onset.
Eligibility
Min Age: 18 Years
Inclusion Criteria4
- First-time occurrence or a history of stroke without significant neurological deficits (baseline mRS score ≤ 1).
- Eligible for treatment with intravenous administration of urokinase or alteplase as assessed by the investigators.
- Patient is willing to participate voluntarily and to sign a written patient informed consent. Informed consent will be obtained from each patient or the subject's legally authorized representative or relatives, or deferred where applicable.
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Exclusion Criteria6
- Female of childbearing potential who is known to be pregnant and/or lactating or who has a positive pregnancy test on admission.
- Known history of drug (narcotics, controlled substances) abuse or addiction in the past year.
- Has an expected survival of less than 90 days due to concurrent malignant tumors or severe systemic diseases Incapable to comply with the protocol due to mental illness or cognitive disorder.
- Paticipants of any interventional drug or device clinical trials within 3 months prior to screening.
- Unsuitable for this study in the opinion of the investigators.
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Interventions
DRUGUrokinase
administered intravenously
DRUGAlteplase
administered intravenously
Locations(16)
View Full Details on ClinicalTrials.gov
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NCT06194968
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