3D-MRE and 2D-MRE for Assessing Cirrhosis and Portal Hypertension
Three-dimensional MR Elastography and Two-dimensional MR Elastography for Assessing Cirrhosis and Portal Hypertension：A Prospective Multicenter Study
Shengjing Hospital
100 participants
Aug 16, 2022
OBSERVATIONAL
Conditions
Summary
How to construct a novel, non-invasive, accurate, and convenient method to achieve prediction of hepatic venous pressure gradient (HVPG) is an important general problem in the management of portal hypertension in cirrhosis. We plan to compare the ability of three demensional-magnetic resonance elastography (3D-MRE) to two demensional-magnetic resonance elastography (2D-MRE) to establish a risk stratification system and perform tailored management for portal hypertension in cirrhosis.
Eligibility
Inclusion Criteria4
- age \> 18 years old
- confirmed cirrhosis (laboratory, imaging and clinical symptoms)
- with 3D-MRE and 2D-MRE within 1 month prior to HVPG measurement
- written informed consent
Exclusion Criteria5
- any previous liver or spleen surgery
- liver cancer; chronic acute liver failure
- acute portal hypertension
- unreliable HVPG, 3D-MRE or 2D-MRE results due to technical reasons
- with liver interventional therapy between HVPG and MRE
Interventions
All imaging studies were performed by using a 3.0-T MRI system (Signa HDx, GE Healthcare) with an eight-channel phasedarray body coil.
HVPG measurements are performed by well-trained interventional radiologists in accordance with standard operating procedures
All imaging studies were performed by using a 3.0-T MRI system (Signa HDx, GE Healthcare) with an eight-channel phasedarray body coil.
HVPG measurements are performed by well-trained interventional radiologists in accordance with standard operating procedures
Locations(1)
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NCT06205992