The Antimicrobial Potential of Diclofenac Sodium as an Intracanal Medicament
The Antimicrobial Potential of Diclofenac Sodium as an Intracanal Medicament During Root Canal Treatment: A Randomized Clinical Trial
British University In Egypt
48 participants
Nov 1, 2025
INTERVENTIONAL
Conditions
Summary
The goal of this randomized clinical trial is to evaluate the capability of the material to exert bacterial reduction of diclofenac sodium versus of that calcium hydroxide paste when these materials are used as intracanal medications in permanent molar teeth with chronic apical periodontitis. The main question\[s\] it aims to answer are: • Will the diclofenac sodium (NSAIDs) possess antimicrobial efficacy to be used effectively as an intracanal medicament similar to that of calcium hydroxide in primary endodontic treatment? Participants will be allocated randomly into three equal groups by using computer generated randomization, according to the type of intracanal medication.
Eligibility
Inclusion Criteria3
- Patients with teeth diagnosed with apical periodontitis
- Periapical Index (PAI) ≥ 2
- The teeth are restorable
Exclusion Criteria5
- Teeth with immature roots
- Non restorable teeth
- Medically compromised patients with systemic complication that would alter the treatment.
- Teeth with internal/external root resorption
- Patient with an allergy to diclofenac sodium
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Interventions
placement of intracanal medication for the three groups will be done after cleaning and shaping of the root canals and it will be left for one week.
placement of intracanal medication for the three groups will be done after cleaning and shaping of the root canals and it will be left for one week.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06207253