RecruitingNCT06215248

Myocardial Dysfunction Evaluation in Lower Extremity Arterial Disease Patients With Deformation Analysis

Assessment of Dysfunction in Left Cardiac Chambers With Strain-analyses in Patients With Lower Extremity Arterial Disease

Sponsor

Tartu University Hospital

Enrollment

162 participants

Start Date

Feb 1, 2024

Study Type

OBSERVATIONAL

Conditions

Heart Failure Peripheral Artery Disease

Summary

Single centre observational study to assess lower extremity arterial disease (LEAD) patients' cardiac dysfunction with strain analyses and to assess connections between cardiac dysfunction, metabolomic changes and target organ damage in LEAD.

Eligibility

Min Age: 35 YearsMax Age: 85 Years

Inclusion Criteria4

Fontaine I-IV class symptoms
Confirmed diagnosis of LEAD
Age 35-85
Has to have at least of the following: hypertension, diabetes, coronary artery disease or the patient smokes

Exclusion Criteria20

Age \<35 or \>85 years
BMI ≥40 kg/m²
Known heart failure in history
Any acute or chronic autoimmune or rheumatic disease
Cardiac structural disease in history: inflammatory, infiltrative diseases, nonischemic cardiomyopathies
Acute coronary syndrome in last 3 months
Moderate to severe cardiac valvular disease
Cardiac valvular disease operative/invasive treatment in history
Cardiac implantable electronic device (CIED)
Transitory ischemic attack or stroke in last 3 months
Severe COPD (GOLD C or D)
Moderate to severe asthma (according to GINA 2022 criteria)
Untreated hypertension (noninvasive blood pressure measurement ≥180/110 mmHg during recruitment)
Chronic severe kidney dysfunction (eGFR \<30 ml/min/1,73 m²)
Malignant tumor with radiation treatment to thorax, oncologic or biologic treatment in history
Chronic hematologic disease (except for anemia)
Severe liver dysfunction
Malignant tumor with \<5 years of remission
Acute or chronic infectious disease
Anemia with hemoglobin \<80 g/L