RecruitingNot ApplicableNCT06216678

The Effects of Healthy Diets With Plant Oils on Heart and Metabolic Health

The Effects of Healthy Diets With Plant Oils on Heart and Metabolic Health: A Randomized, Crossover, Controlled-feeding Study


Sponsor

Penn State University

Enrollment

52 participants

Start Date

Sep 9, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This study will examine the effect of a healthy diet containing cottonseed oil compared to healthy diets containing other commonly consumed plant oils on biomarkers of heart and metabolic health after 4 weeks.


Eligibility

Min Age: 25 YearsMax Age: 60 Years

Inclusion Criteria6

  • LDL-C ≥100 mg/dL and ≤190 mg/dL
  • BMI of 25-40 kg/m2
  • Blood pressure <140/90 mmHg
  • Fasting blood glucose <126 mg/dL
  • Fasting triglycerides <350 mg/dL
  • ≤10% change in body weight for 6 months prior to enrollment

Exclusion Criteria17

  • Type 1 or type 2 diabetes or fasting blood glucose ≥126 mg/dL
  • Prescription of anti-hypertensive, lipid lowering or glucose lowering drugs
  • Intake of supplements that affect the outcomes of interest and unwilling to cease during the study period
  • Diagnosed liver, kidney, or autoimmune disease
  • Prior cardiovascular event (e.g., stroke, heart attack)
  • Current pregnancy or intention of pregnancy within the next 6 months
  • Lactation within prior 6 months
  • Follows a vegetarian or vegan diet
  • Food allergies/intolerance/sensitives/dislikes of foods included in the study menu
  • Antibiotic use within the prior 1 month
  • Oral steroid use within the prior 1 month
  • Use of tobacco or nicotine containing products with in the past 6 months
  • Cancer any site within the past 10 years (eligible if ≥10 years without recurrence) or non-melanoma skin cancer with in the past 5 years (eligible if ≥5 years without recurrence)
  • Participation in another clinical trial within 30 days of baseline
  • Currently following a restricted or weight loss diet
  • Prior bariatric surgery
  • Intake of >14 alcoholic drinks/week and/or lack of willingness to consume a maximum of two standard drinks per week while enrolled in the study and/or not willing to avoid alcohol consumption for 48 hour prior to test visits

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Interventions

OTHERHealthy Dietary Pattern with Cottonseed Oil

Cottonseed Oil

OTHERHealthy Dietary Pattern with Fatty Acid-Matched Plant Oils

Plant oil blend fatty acid matched

OTHERHealthy Dietary Pattern with PUFA:SFA Ratio-Matched Plant Oil

Plant oil with matched PUFA to SFA ratio


Locations(1)

The Pennylvania State University

University Park, Pennsylvania, United States

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NCT06216678


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