RecruitingNot ApplicableNCT06303869

Deep Brain Stimulation Motor Ventral Thalamus (VOP/VIM) for Restoration of Speech and Upper-limb Function in People With Subcortical Stroke

Sponsor

Jorge Gonzalez-Martinez

Enrollment

10 participants

Start Date

Jun 20, 2025

Study Type

INTERVENTIONAL

Conditions

Cardiovascular Diseases Central Nervous System Diseases Stroke Brain Disease Nervous System Diseases

Summary

The goal of this study is to verify whether the use of deep brain stimulation can improve motor function of the hand and arm and speech abilities for people following a stroke. Participants will undergo a surgical procedure to implant deep brain stimulation electrode leads. The electrodes will be connected to external stimulators and a series of experiments will be performed to identify the types of movements that the hand and arm can make and how speech abilities are affected by the stimulation. The implant will be removed after less than 30 days. Results of this study will provide the foundation for future studies evaluating the efficacy of a minimally-invasive neuro-technology that can be used in clinical neuro-rehabilitation programs to restore speech and upper limb motor functions in people with subcortical strokes, thereby increasing independence and quality of life.

Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study tests deep brain stimulation (DBS) — a procedure that implants a small device to send electrical signals to specific brain areas — to help restore speech and arm function in people who experienced a stroke that damaged areas beneath the brain's outer surface. The study focuses on people who still have speech difficulties (dysarthria) more than 6 months after their stroke. **You may be eligible if...** - You are between 18 and 75 years old - You had a single ischemic or hemorrhagic stroke more than 6 months ago that caused speech difficulties (dysarthria) - You speak English - Your speech test scores indicate significant impairment in at least 4 speech categories (or 3 categories plus a communication participation score) **You may NOT be eligible if...** - You have had multiple strokes or a stroke in the outer brain cortex - You have a pacemaker or other implanted devices incompatible with DBS - You have dementia, active psychiatric illness, or substance use disorder - You have conditions that increase surgical risk (such as uncontrolled bleeding disorders) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEDeep Brain Stimulation (DBS) of the Motor Thalamus

All participants enrolled in this group will undergo a surgical procedure to implant deep brain stimulation electrode leads. The electrodes will be connected to external stimulators and a series of experiments will be performed to identify the types of movements that the hand and arm can make and how speech abilities are affected by the stimulation. The implant will be removed after less than 30 days.