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RecruitingNCT06227468

A Clinical Study to Map the HLA Genomic Region in the Greek Population

A Clinical Study to Map the HLA GENomic Region and Its potEntial aSsocIation With Selected diSeases in the Greek Population

Sponsor

Athens LifeTech Park

Enrollment

12,000 participants

Start Date

Dec 12, 2023

Study Type

OBSERVATIONAL

Conditions

Cardiovascular DiseasesMetabolic DiseaseHealthyNeurologic DisorderGastrointestinal DiseasesPsychiatric DisorderRespiratory DiseaseHaematologic DiseaseRheumatologic DiseaseChronic Renal Failure

Summary

The aim of GENESIS clinical study is to map the HLA genomic region in the Greek population and evaluate possible correlations with selected underlying diseases.

Eligibility

Min Age: 18 Years

Inclusion Criteria3

  • The study will include adult subjects (age ≥ 18) that:
  • possess a Greek social security number and are visiting hospitals/clinics, and/or other private laboratory institutions (incl. clinics and health care groups) as part of standard clinical practice in Greece,
  • are willing and able to provide written informed consent to participate in the study according to the study protocol.

Exclusion Criteria7

  • Subjects not able to provide written informed consent (e.g. ICU patients, mental illness patients, lack of legal capacity).
  • Subjects who have had an allogeneic (non-self-donor):
  • bone marrow transplant
  • stem cell transplant
  • blood transfusion less than two weeks prior to buccal swab sample collection
  • liver transplant
  • Subjects who participated in an interventional clinical trial in the past that according to the subject's physician opinion might have had an impact on their HLA genome.

Locations(8)

2nd Propaedeutic Department of Internal Medicine, Attikon University General Hospital

Chaïdári, Attica, Greece

2nd Department of Neurology, AHEPA University Hospital

Thessaloniki, Thessaloniki, Greece

Department of Respiratory Medicine, University General Hospital of Alexandroupolis

Alexandroupoli, Thrace, Greece

Department of Infectious Diseases, 2nd Department of Internal Medicine, University General Hospital of Alexandroupolis

Alexandroupoli, Greece

Department of Cardiology, University General Hospital of Heraklion

Heraklion, Greece

Department of Rheumatology, University Hospital of Heraklion

Heraklion, Greece

Department of Respiratory, University Hospital of Ioannina

Ioannina, Greece

Department of Haematology, University General Hospital of Larissa

Larissa, Greece

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NCT06227468

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