A Mechanistic Trial of the Neurobiology of Extinction Learning and Intraparietal Sulcus Stimulation
University of Pennsylvania
120 participants
Apr 29, 2024
INTERVENTIONAL
Conditions
Summary
This study will be the first of its kind to explore the impact of continuous theta burst stimulation (cTBS) to the intraparietal sulcus (IPS) on arousal symptoms among patients with posttraumatic stress disorder (PTSD). The investigators will demonstrate that IPS cTBS results in significant reduction in arousal (measured by startle response) compared to sham cTBS, that IPS cTBS interacts with extinction training to further improve arousal, and that there is a dose/response effect of cTBS on arousal. The investigators will also demonstrate that IPS cTBS significantly improves retention of extinction learning, the experimental analogue of exposure therapy.
Eligibility
Inclusion Criteria3
- Adult aged 18-60
- Meets Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria for PTSD according to the Clinician-Administered PTSD Scale for DSM-5
- No metal implants
Exclusion Criteria10
- Pregnancy
- Seizure disorder or epilepsy
- Increased risk of seizure
- Non-English speaking
- Any medical condition that increases risk for fMRI or cTBS
- Medical implant
- Hearing loss sufficient to interfere with startle
- Claustrophobia
- Recent medication or therapy changes (in the past 8 weeks)
- Current severe substance use disorder
Interventions
Continuous Theta Burst Stimulation delivered to the Intraparietal Sulcus
Sham Continuous Theta Burst Stimulation
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06234969