RecruitingNCT06236048

Energetics and Glutamate in Schizophrenia

Sponsor

King's College London

Enrollment

75 participants

Start Date

Mar 4, 2024

Study Type

OBSERVATIONAL

Conditions

Schizophrenia

Summary

The goal of this case-control study is to compare brain glutamate, glucose utilisation, lactate production and brain activity in healthy volunteers and people with a diagnosis of schizophrenia. It investigates the following main questions: Whether, compared to healthy volunteers, participants with schizophrenia show: 1. reduction in brain glucose utilisation 2. increased brain lactate 3. greater variability in brain glutamate Participants will be asked to have a screening visit, a MRI brain scan and a PET-MRI brain scan.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This research study is examining brain energy metabolism and a chemical called glutamate in people with schizophrenia — both those who respond well to standard medications and those who are treatment-resistant — compared to healthy volunteers. No experimental treatment is given. **You may be eligible if...** - You are a healthy person with no history of psychiatric illness, OR - You have been diagnosed with schizophrenia and are currently taking antipsychotic medication - You are either in remission (treatment-responsive group) or have treatment-resistant schizophrenia (taking clozapine or other medications) - You are willing and able to give informed consent **You may NOT be eligible if...** - You are pregnant or breastfeeding - You do not have the mental capacity to consent to participation Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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