High Definition Transcranial Direct Current Stimulation (HD-tDCS) for Refractory Epilepsy
The Efficacy, Safety and Mechanism of High Definition Transcranial Direct Current Stimulation (HD-tDCS) in the Treatment of Refractory Epilepsy
Anhui Medical University
90 participants
Feb 12, 2024
INTERVENTIONAL
Conditions
Summary
To observe the clinical effect and safety of transcranial electrical stimulation on patients with refractory epilepsy before and after treatment and analyze its therapeutic mechanism.
Eligibility
Inclusion Criteria4
- Clinical diagnosis of refractory epilepsy
- Right-handed and aged 18-50 years old and primary school education or above;
- No major neurological or mental illness, no head injury, alcohol dependence or drug dependence;
- During the experiment, the subjects did not smoke, drink, get sick and take psychotropic drugs, and there were no major life events that caused mood changes.
Exclusion Criteria3
- organic brain injury, neurological diseases or serious physical diseases;
- Have a history of substance abuse and drug dependence, or have used antipsychotic drugs in the past three months, and have serious suicidal tendencies;
- There are contraindications for MRI or EEG or transcranial magnetic stimulation.
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Interventions
Improvement of cortical excitability, unilateral stimulation was effective, and no side effects were observed
Improved cortical excitability, the effect was more obvious than unilateral stimulation, the effect lasted longer, and no side effects were observed
The sham stimulation is mainly used for blank control, control variables, and exclude the interference of other factors
Locations(1)
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NCT06241963