Benzodiazepine Impact on Cognitive Function: fNIRs and PET/MRI Study

This study uses advanced brain imaging (fNIRS and PET/MRI) to examine how long-term use of benzodiazepines (anti-anxiety or sleep medications like diazepam or lorazepam) affects brain function and insulin action in the brain, which may be related to memory and cognitive problems. **You may be eligible if...** - You have been taking benzodiazepines continuously for at least 3 months (or you are a matched non-user participating as a control) - You have at least 6 years of education - You abstained from alcohol, coffee, and psychoactive substances in the 24 hours before the exam **You may NOT be eligible if...** - You have brain damage from any cause (trauma, dementia, epilepsy, tumors) - You have severe systemic diseases such as cancer - You had a stroke or cerebrovascular event in the past 3 months - You have a history of substance abuse (alcohol, opioids) beyond benzodiazepines - You are unable to cooperate with brain imaging or assessments Talk to your doctor to see if this trial is right for you.