Neoadjuvant Immunochemotherapy for LAOSCC

This study is testing a treatment approach called neoadjuvant immunochemotherapy — combining immunotherapy and chemotherapy before surgery — for people with locally advanced oral cavity cancer (cancer in the mouth). The goal is to shrink the cancer before removal to improve surgical outcomes. **You may be eligible if...** - You have a confirmed diagnosis of squamous cell carcinoma of the oral cavity (tongue, gums, cheek, floor of mouth, hard palate, or molar area) - Your cancer is Stage III or IVA (locally advanced but not yet spread to distant organs) - You are in good physical condition (ECOG score 0 or 1) - You have at least one measurable tumor on imaging - Your blood counts, liver, kidney, and clotting function meet minimum requirements **You may NOT be eligible if...** - You have a known allergy to any components of the treatment - You have a history of another cancer in the past 5 years (unless cured) - You have previously had radiation to the head and neck - You are receiving another immunotherapy treatment - You are pregnant or breastfeeding - You have active hepatitis B or C, or significant heart disease Talk to your doctor to see if this trial is right for you.