Oral Squamous Cell Carcinoma Clinical Trials

18 recruiting

Oral Squamous Cell Carcinoma Trials at a Glance

26 actively recruiting trials for oral squamous cell carcinoma are listed on ClinicalTrialsFinder across 6 cities in 6 countries. The largest study group is Phase 2 with 9 trials, with the heaviest enrollment activity in Guangzhou, New York, and Cleveland. Lead sponsors running oral squamous cell carcinoma studies include Hospital of Stomatology, Wuhan University, Centre hospitalier de l'Université de Montréal (CHUM), and Shanghai Jiao Tong University School of Medicine.

Browse oral squamous cell carcinoma trials by phase

Treatments under study

About Oral Squamous Cell Carcinoma Clinical Trials

Looking for clinical trials for Oral Squamous Cell Carcinoma? There are currently 18 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Oral Squamous Cell Carcinoma trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Oral Squamous Cell Carcinoma clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 26 trials

Recruiting
Phase 2Phase 3

A Study Evaluating the Safety and Efficacy of PRV111, PRV211, and PRV131 in Subjects With Oral and Lung Cancers

Oral Squamous Cell Carcinoma
Privo Technologies40 enrolled4 locationsNCT05893888
Recruiting
Phase 2

Antibiotic Treatment Effects on Intratumoral Bacteria Modulation in Surgical Patients With Oral Cancer

Head and Neck CarcinomaHead and Neck CancerOral Cancer+1 more
Case Comprehensive Cancer Center30 enrolled1 locationNCT06627270
Recruiting
Not Applicable

"Ultra-High Frequency intraOral UltraSonography of the TONgue" (HOUSTON)

Oral Squamous Cell Carcinoma
University of Pisa400 enrolled1 locationNCT06336941
Recruiting
Phase 2

A Study of Sacituzumab Govitecan in Combination With Cetuximab in People With Head and Neck Squamous Cell Cancer (HNSCC)

Squamous Cell Carcinoma of Head and NeckOral Cavity CancerNasal Cavity Cancer+9 more
Memorial Sloan Kettering Cancer Center40 enrolled7 locationsNCT07063212
Recruiting
Phase 3

Sintilimab Plus Chemotherapy as Neoadjuvant and Adjuvant Treatment for Locally Advanced Oral Squamous Cell Carcinoma

Oral Squamous Cell Carcinoma (OSCC)Locally Advanced Oral Squamous Cell Carcinoma
Qunxing Li,MD104 enrolled1 locationNCT07371611
Recruiting

Dual-energy CT vs. MRI in the Evaluation of Squamous Cell Carcinomas of the Oral Cavity and Oropharynx

Oral Squamous Cell CarcinomaOropharyngeal Squamous Cell Carcinoma
University Hospital, Strasbourg, France30 enrolled1 locationNCT07343271
Recruiting
Not Applicable

Enhancing Oral Cancer Awareness

PreventionOral CancerOral Cancer , Oral Squamous Cell Carcinoma, Oral Cavity Cancer+3 more
Virginia Commonwealth University60 enrolled1 locationNCT06682494
Recruiting

Prospective Cohort Study on Oral Microbiome Changes in Patients With Locally Advanced Oral Squamous Cell Carcinoma Following Neoadjuvant Chemoimmunotherapy

Locally Advanced Oral Squamous Cell Carcinoma
Zhujiang Hospital32 enrolled1 locationNCT07111455
Recruiting
Not Applicable

Proactive Risk-based Optimization & Notifications for Treatment & Outcomes in Head & Neck Cancer

Oral Cancer , Oral Squamous Cell Carcinoma, Oral Cavity CancerHead &Amp;Amp; Neck Squamous Cell CarcinomaLarynx Squamous Cell Carcinoma
Centre hospitalier de l'Université de Montréal (CHUM)85 enrolled1 locationNCT07180901
Recruiting

A Bidirectional Observational Clinical Study of NAIC in the Treatment of Tumor Regression Patterns in LA-OSCC and LA-OPSCC

Oropharyngeal Squamous Cell Carcinoma (SCC)Oral Squamous Cell Carcinoma (OSCC)
Zhujiang Hospital35 enrolled1 locationNCT07133958
Recruiting
Not Applicable

Sentinel Node Biopsy Versus Limited Elective Neck Dissection in Early Cancers of Oral Cavity NoDe Negative

Sentinel Lymph Node Biopsy (SLNB)Sentinel Lymph NodeSentinel Lymph Node Biopsy+4 more
Tata Memorial Hospital508 enrolled3 locationsNCT05774483
Recruiting
Phase 2

Neoadjuvant Low-Dose Radiotherapy Combined With Adebrelimab and Single-Agent Albumin-Bound Paclitaxel Chemotherapy for Early-Stage Oral Squamous Cell Carcinoma: A Prospective, Single-Arm Clinical Trial

Early-Stage Oral Squamous Cell Carcinoma
Jun Jia30 enrolled1 locationNCT07007364
Recruiting
Phase 2

The Combination of Adebrelimab and TP Regimen for Neoadjuvant Therapy in Patients With Stage IVB Oral Squamous Cell Carcinoma

Clinical IVb Stage Oral Squamous Cell Carcinomas Patients
Hospital of Stomatology, Wuhan University35 enrolled1 locationNCT06277791
Recruiting

People Living With HIV, Oral and Oropharyngeal Cancer, and Health Equity

HIV InfectionsOral Squamous Cell CarcinomaOropharyngeal Squamous Cell Carcinoma
University of California, San Francisco144 enrolled1 locationNCT06055868
Recruiting

SYsteMatical Trained learnIng aLgorithms for Oral carcInogenesiS Interpretation by Optical Coherence Tomography

Oral Squamous Cell CarcinomaOral LeukoplakiaOral Lichen Planus+3 more
University of Palermo200 enrolled1 locationNCT06321003
Recruiting
Phase 3

Neoadjuvant Immunochemotherapy for LAOSCC

Oral Squamous Cell CarcinomaLocally Advanced Head and Neck Carcinoma
Lai-ping Zhong134 enrolled1 locationNCT06258811
Recruiting

Validity of Viome's Oral/throat Cancer Test

Oral Squamous Cell CarcinomaOropharyngeal Squamous Cell CarcinomaOral and Throat Cancer
Viome1,000 enrolled2 locationsNCT06174428
Recruiting

Detection of Oral and Throat Cancers Using OralViome Cancer Testing System

Premalignant LesionOral Squamous Cell CarcinomaOropharynx Squamous Cell Carcinoma
Viome475 enrolled1 locationNCT05451303
Recruiting
Not Applicable

Tobacco, Alcohol and Cancerization of the Oral Mucosa (TACO)

Oral Squamous Cell Carcinomas
Centre Leon Berard30 enrolled1 locationNCT06425146
Recruiting
Not Applicable

Tolerance and Benefits of Mandibular Advanced Device for Snoring and Sleep Apnea in Oropharyngeal Cancer.

Oral CancerPharynx CancerSleep Apnea+2 more
Centre hospitalier de l'Université de Montréal (CHUM)35 enrolled1 locationNCT05719779