RecruitingNot ApplicableNCT06261658
Improving the Quality of Cryopreserved Ovarian Tissue Reimplantation Using Platelet-enriched Autologous Plasma
Sponsor
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Enrollment
45 participants
Start Date
Mar 1, 2024
Study Type
INTERVENTIONAL
Conditions
Summary
The study is aimed to evaluate the effects of intraovarian injection of autologous Platelet-enriched Autologous Plasma on the outcomes of orthotopic transplantation of cryopreserved ovarian tissue.
Eligibility
Sex: FEMALE
Inclusion Criteria7
- request for cryopreserved ovarian tissue transplantation;
- premature ovarian failure or irregular mentrual cycles;
- negative test for HIV, HBV, HCV, Treponema pallidum;
- negative PAP test;
- oncological authorization;
- absence of neoplastic contamination in the cryopreserved ovarian tissue;
- Informed consent
Exclusion Criteria8
- neoplastic contamination in cryopreserved ovarian tissue;
- history of endometriosis;
- endocrinological disorders present and not treated (uncompensated thyroid dysfunction, diabetes (type 1, type 2);
- body mass index (BMI) >30 kg/m2;
- circulating platelet level < 150,000 / mml;
- bacterial infection;
- ongoing use of anticoagulants;
- bleeding diathesis.
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Interventions
PROCEDURECryopreserved Ovarian Tissue Reimplantation
Cryopreserved Ovarian Tissue Reimplantation Using Platelet-enriched Autologous Plasma
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06261658
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