RecruitingNot ApplicableNCT06268600

The Protection of Thyroid Function in IMRT for Nasopharyngeal Carcinoma

The Protection of Thyroid Function in IMRT for Nasopharyngeal Carcinoma: A Retrospective Study

Sponsor

Jiangxi Provincial Cancer Hospital

Enrollment

320 participants

Start Date

Jan 1, 2019

Study Type

INTERVENTIONAL

Conditions

Nasopharyngeal Cancer Nasopharyngeal Carcinoma Hypothyroidism

Summary

This study aimed to reduce radiation-induced thyroid injury without compromising control of the cervical region by optimizing the delineation of the cervical lymph node drainage area.

Eligibility

Min Age: 18 YearsMax Age: 75 Years

Inclusion Criteria12

The pathological diagnosis was newly diagnosed non-keratinizing squamous cell carcinoma nasopharyngeal carcinoma.
The clinical stage is T1-4N0-3M0 (stage I\~IVa, UICC/AJCC 8th edition);
There is no history of hypothyroidism or hyperthyroidism before treatment;
Using intensity-modulated radiotherapy technology,
Complete radical dose radiotherapy;
KPS≥70 points;
Age 18-70 years old;
Male or female who is not pregnant or lactating;
Hematological examination: white blood cells \> 4×109/L, neutrophils \> 2×109/L, hemoglobin \> 90g/L, platelets \> 100×109/L;
Liver function: ALT, AST \< 1.5×ULN, ALP \< 2.5×ULN, bilirubin \< ULN.
Renal function: creatinine \> 60 ml/min;
The patient signs the informed consent form;

Exclusion Criteria7

WHO pathological classification is keratinizing squamous cell carcinoma or basaloid carcinoma;
palliative treatment;
Have a history of other malignant tumors;
Pregnant or lactating women (women of childbearing age should consider taking a pregnancy test, and patients are required to use effective contraception during treatment);
Have a history of neck surgery;
Have a history of hyperthyroidism or hypothyroidism.
Previous history of head and neck radiation therapy;

Interventions

RADIATIONModified neck target volume delineation

Modified neck target volume delineation method was used to define the inner boundary of regions III and IVa as the outer edge of the common carotid artery.