Efficacy and Safety of Toludesvenlafaxine Hydrochloride Sustained-release Tablets Versus Desvenlafaxine Succinate Sustained-release Tablets Targeting Anhedonia in Patients With Major Depression Disorder

This study is comparing two antidepressant medications — toludesvenlafaxine and desvenlafaxine — specifically in people with major depression who also experience a loss of pleasure or enjoyment (called anhedonia). Researchers want to know which drug works better for this symptom. **You may be eligible if...** - You are between 18 and 65 years old - You have been diagnosed with major depressive disorder - You have a high score on depression rating scales, including the anhedonia scale - You are willing to participate and sign informed consent **You may NOT be eligible if...** - You are allergic to either study medication - You have serious thoughts of self-harm or suicide - You have bipolar disorder, schizophrenia, or other serious psychiatric conditions Talk to your doctor to see if this trial is right for you.