RecruitingNCT06272240

Tumor Microenvironment in Ovarian Cancer

Study of the Role of the Tumor Microenvironment in Ovarian Cancer

Sponsor

University of Udine

Enrollment

50 participants

Start Date

Jan 2, 2024

Study Type

OBSERVATIONAL

Conditions

Ovarian Cancer Stage III Ovarian Cancer Stage IV

Summary

A detailed understanding of molecular mechanism of cancer genesis is fundamental to develop innovative and personalized therapies. The new frontier in biomedical research is represented by organoids, a three-dimensional cell culture system obtained from a tissue fragment that accurately reproduces the essential properties of the original tissue in vitro, which could provide a valuable model for explanation of ovarian cancers pathogenesis and will allow to predict the response to a specific therapy. With this research project, we expect to generate ovarian cancer organoids to characterize in vitro interactions and molecular pathway among tumor cells, immune cells, and resident microbiota (intratumoral bacteria and/or microbial-derived molecules).

Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is researching the tumor microenvironment in ovarian cancer — the mix of cells and signals surrounding the tumor — to better understand why some patients respond to treatment and others do not. Tissue samples will be collected during surgery. **You may be eligible if...** - You are between 18 and 80 years old - You have been diagnosed with serous ovarian carcinoma (a specific type of ovarian cancer) - Your cancer is at an advanced stage (FIGO stage III or IV) - You are having surgery as part of your treatment - Your BMI is 30 or below **You may NOT be eligible if...** - You are on or have recently been on immunosuppressive medication - You have an immune deficiency condition - You have received chemotherapy for another cancer in the past year Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHEROvarian Cancer Organoids

To characterize in vitro interactions and molecular pathway among tumor cells, immune cells, and resident microbiota (intratumoral bacteria and/or microbial-derived molecules)