RecruitingPhase 2Phase 3NCT06273527

Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol (R33)

Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol


Sponsor

University of California, San Diego

Enrollment

128 participants

Start Date

Oct 1, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The proposed project aims to test the cognitive and neural effects of a cognitive training in a sample of individuals seeking treatment for anxiety, depression, or traumatic stress symptoms. Participants will be randomly assigned to one of two groups. Group 1 will receive a computer-based program that is designed as a cognitive training intervention and Group 2 will receive a similar computer-based exercise that researchers think will be less effective in training thinking skills (also known as a control or sham condition). Participants will be compared on cognitive performance and brain response during cognitive tasks from baseline to post-treatment.


Eligibility

Min Age: 21 YearsMax Age: 55 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a brain training program can reduce repetitive negative thinking — the mental habit of dwelling on worries or regrets — in adults with mood disorders, anxiety disorders, or trauma-related conditions. This kind of thinking is common across many psychiatric diagnoses. **You may be eligible if...** - You are between 21 and 55 years old - You speak fluent English - You have a diagnosis of a mood disorder, anxiety disorder, or trauma-related condition - You experience clinically elevated repetitive negative thinking (rumination or worry) - You are an outpatient (not currently hospitalized) **You may NOT be eligible if...** - You have a history of psychosis or bipolar I disorder - You have a serious substance use disorder in the past year - You are acutely suicidal - You have a neurological condition such as traumatic brain injury or dementia Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALCOGENT

COGENT is based on a working memory capacity task, which requires individuals to memorize stimuli while simultaneously completing a secondary puzzle task.

OTHERSham Program

The Sham Program will be a similar task which researchers think will be less effective in training thinking skills.


Locations(1)

UC San Diego

San Diego, California, United States

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NCT06273527


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