Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol (R33)
Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol
University of California, San Diego
128 participants
Oct 1, 2024
INTERVENTIONAL
Conditions
Summary
The proposed project aims to test the cognitive and neural effects of a cognitive training in a sample of individuals seeking treatment for anxiety, depression, or traumatic stress symptoms. Participants will be randomly assigned to one of two groups. Group 1 will receive a computer-based program that is designed as a cognitive training intervention and Group 2 will receive a similar computer-based exercise that researchers think will be less effective in training thinking skills (also known as a control or sham condition). Participants will be compared on cognitive performance and brain response during cognitive tasks from baseline to post-treatment.
Eligibility
Inclusion Criteria6
- age 21-55
- fluent in English
- diagnosis of mood, anxiety, or traumatic stress disorder
- clinically elevated repetitive negative thinking
- outpatient status
- week stability if taking selective serotonin reuptake inhibitor (SSRI) medications
Exclusion Criteria10
- past year diagnosis of severe alcohol or moderate or greater substance use disorder
- lifetime history of psychotic or bipolar I disorder
- acute suicidality necessitating immediate clinical intervention
- neurodegenerative or neurodevelopmental disorders
- history of moderate or severe traumatic brain injury or other known neurological condition
- sensory deficits that would preclude completing tasks
- conditions unsafe for completing MRI scanning (e.g., metal in body)
- current pregnancy
- currently receiving psychosocial treatment
- currently receiving psychiatric pharmacotherapy, except SSRIs
Interventions
COGENT is based on a working memory capacity task, which requires individuals to memorize stimuli while simultaneously completing a secondary puzzle task.
The Sham Program will be a similar task which researchers think will be less effective in training thinking skills.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06273527