RecruitingNot ApplicableNCT06273631

Effect of Changes in Carbohydrate Intake Patterns on Glucose Control in Patients With Type 1 Diabetes

Sponsor

Yang Tao

Enrollment

80 participants

Start Date

Aug 1, 2024

Study Type

INTERVENTIONAL

Conditions

Type 1 Diabetes Diet Intervention Glucose Control

Summary

The blood glucose fluctuates greatly in T1DM patients, especially in the middle and late stages of the disease, and carbohydrate (CHO) is the main determinant of postprandial glucose response (PGR). Based on the previous investigation to understand how nutritional habits affect blood glucose control, we will conduct dietary intervention studies in T1DM patients to explore whether the adjustment of dietary pattern is beneficial to blood glucose control, and further explore the relevant mechanism through the detection of related metabolic indicators.

Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at how changing the timing and pattern of carbohydrate (starchy and sugary food) intake throughout the day affects blood sugar levels in people with type 1 diabetes. The goal is to find dietary patterns that lead to better glucose control. **You may be eligible if...** - You have been diagnosed with type 1 diabetes - You are between 18 and 70 years old - Your HbA1c (a measure of average blood sugar over 3 months) is 11% or below - Your BMI is between 18 and 25 - You have been on a stable insulin treatment plan for at least 2 months **You may NOT be eligible if...** - You are in the early "honeymoon" phase after diagnosis when your pancreas may still produce some insulin - You are pregnant or planning to become pregnant - You follow a vegetarian diet or are currently trying to lose weight Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERdiverse carbohydrate diet

Carbohydrate provides 45\~55% of total dietary energy, protein 15\~20%, and fat 25 \~35%. Among them, 45\~50% of carbohydrate supply sources are refined grains, 45\~50% of carbohydrate supply sources are whole grains or beans. The total energy is divided into 3 meals per day. The breakfast provides 25\~30% of total energy, lunch 30\~40%，and dinner 30\~35%.

OTHERmoderate carbohydrate diet

Carbohydrate provides 45\~55% of total dietary energy, protein 15\~20%, and fat 25 \~35%. Among them, 90\~95% of carbohydrate supply sources are refined grains. The total energy is divided into 3 meals per day. The breakfast provides 25\~30% of total energy, lunch 30\~40%，and dinner 30\~35%.