Interaction Between Early Trauma and Odor-induced Dopamine Release
Consequence of Early Trauma on Odor Hedonics Appreciation and DOpamine Release
Hôpital le Vinatier
30 participants
Apr 27, 2026
INTERVENTIONAL
Conditions
Summary
This prospective, double-blind, parallel-group controlled trial aims to investigate the consequence of early trauma on dopamine release evoked by positive valence odors.
Eligibility
Inclusion Criteria5
- Aged 18 years or older
- Have been selected based on the Childhood Trauma Questionnaire score
- Non-smoker
- Be able to speak and read French
- Sign a consent form before intervention.
Exclusion Criteria7
- A pre-existing condition that affects olfaction including congenital anosmia, upper respiratory tract infection, nasal and/or sinus disease,
- Be on medication, with the exception of oral contraceptives
- Pregnant or breast-feeding woman (check with urine pregnancy tests);
- Contraindications to TMS or MRI (implanted medical devices or metallic foreign body in the head);
- Psychiatric disorders
- Use of psychotropic drugs
- Have participated in a study involving the injection of a radiotracer during the year
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
In the "presence of early trauma" arm, 15 participants are recruited based on a high Childhood Trauma Questionnaire total score.
In the "absence of early trauma" arm, 15 participants are recruited based on a low Childhood Trauma Questionnaire total score.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06284382