Analgesia Nociception Index to Explore Autonomic Nervous System in Patients With Continuous Renal Replacement Therapy

This observational study examines how the autonomic nervous system (the part of the nervous system that controls involuntary functions like heart rate) responds when critically ill patients with fluid overload undergo fluid removal through continuous kidney replacement therapy. Researchers will use a non-invasive index called the Analgesia Nociception Index to measure the balance between sympathetic and parasympathetic activity during this process. Eligible participants are ICU patients on continuous renal replacement therapy who are awake or lightly sedated, have a regular heart rhythm, and are monitored with invasive blood pressure and central venous lines. Participation is observational and does not change the patient's standard treatment. This summary was prepared to help patients understand the study in plain language.