Critically Ill Clinical Trials

13 recruiting

Critically Ill Trials at a Glance

50 actively recruiting trials for critically ill are listed on ClinicalTrialsFinder across 6 cities in 30 countries. The largest study group is Not Applicable with 12 trials, with the heaviest enrollment activity in London, São Paulo, and Hamilton. Lead sponsors running critically ill studies include Intensive Care Unit, John Hunter Hospital, Hospices Civils de Lyon, and Assistance Publique - Hôpitaux de Paris.

Browse critically ill trials by phase

Treatments under study

About Critically Ill Clinical Trials

Looking for clinical trials for Critically Ill? There are currently 13 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Critically Ill trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Critically Ill clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 50 trials

Recruiting
Not Applicable

Reliability of Minimally Trained Operator's Velocity-Time Integral Measurement Guided by Artificial Intelligence VTI

Critically Ill PatientsVelocity-time Integral MeasurementTissue Hypoperfusion
Assistance Publique - Hôpitaux de Paris100 enrolled3 locationsNCT06486467
Recruiting
Not Applicable

The Effect of Muscle Stimulation and Amino Acid Intake on Protein Metabolism During Critical Illness

Muscle Wasting in Critically Ill
Wageningen University30 enrolled1 locationNCT07430969
Recruiting
Phase 3

Comparative Efficacy and Safety of Propofol-Ketamine Combination Versus Propofol Monotherapy in Geriatric Patients Under Invasive Ventilation

PneumoniaSeptic ShockThe Critically Ill Patient is Requiring Intubation
Helwan University41 enrolled1 locationNCT07530146
Recruiting

Induction Agent Choice With Early Mortality and Prognostic Outcomes in Critically Ill Patients

OxygenationAirway ManagementCritically Ill+3 more
Zeliha Alicikus4 enrolled1 locationNCT07222007
Recruiting

Blood Sampling Pre- and Post-Propofol Administration to Characterize the Blood Proteome Using Different Research Assays

Critically Ill Surgical Patients
National Institutes of Health Clinical Center (CC)10 enrolled1 locationNCT07295795
Recruiting

Epidemiology and Processes of Care for Renal Replacement Therapy in Acute Kidney Injury in Latin America

Acute Kidney InjuryRenal Replacement Therapy for Acute Kidney Injury in ICUDialysis+1 more
University of Alabama at Birmingham1,000 enrolled15 locationsNCT07262320
Recruiting
Phase 4

Effects of Donor-recipient Sex-matched Blood Transfusion on Patient Outcomes

CardiovascularRed Blood Cell TransfusionsSex Differences+3 more
Michelle Zeller11,082 enrolled8 locationsNCT06840756
Recruiting
Not Applicable

Accuracy and Safety of the Syai Tag System for Continuous Glucose Monitoring in Intensive Internal Care Unit

Diabetes MellitusSepsisCritically Ill Intensive Care Unit Patients+1 more
University Medical Centre Maribor100 enrolled1 locationNCT07448805
Recruiting
Phase 3

Advancing Brain Outcomes in Pediatric Critically Ill Patients Sedated With Volatile AnEsthestic Agents

Intensive Care Units, PediatricAnesthetics, InhalationMechanically Ventilated, Critically Ill Children
Sunnybrook Health Sciences Centre60 enrolled3 locationsNCT05867472
Recruiting
Not Applicable

Feasibility of End-tidal Oxygen Concentration Monitoring During Preoxygenation for Intubation in the Intensive Care Unit.

Critically Ill
Centre Hospitalier Régional d'Orléans30 enrolled1 locationNCT05409573
Recruiting

SOFA-2 Score in Turkish ICUs

Critically Ill Intensive Care Unit PatientsIntensive Care Unit Patients
Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital5,200 enrolled1 locationNCT07338240
Recruiting

Clinical Characteristics and Epidemiology of Chronic Critically Ill Patients in China

Chronic Critically Ill
West China Hospital459 enrolled1 locationNCT07372742
Recruiting

Analgesia Nociception Index to Explore Autonomic Nervous System in Patients With Continuous Renal Replacement Therapy

Critically Ill
Hospices Civils de Lyon30 enrolled1 locationNCT06285162
Recruiting
Not Applicable

Quality Improvement Intervention for a Safe Antimicrobial Use Reduction in Critically Ill Patients

Antimicrobial StewardshipInfectionCritically Ill Intensive Care Unit Patients
Hospital Sirio-Libanes9,000 enrolled9 locationsNCT07093450
Recruiting

MuScle WastIng and DysphaGia iN CriticAlly IlL Patients (SIGNAL)

Swallowing DisordersCritical IllnessDysphagia+1 more
Barts & The London NHS Trust160 enrolled1 locationNCT07076524
Recruiting
Not Applicable

Protein Delivery in Intermittent and Continuous Enteral Nutrition in ICU Patients

Muscle Wasting in Critically Ill
University Hospital, Basel, Switzerland68 enrolled1 locationNCT03587870
Recruiting

Opportunistic PK/PD Trial in Critically Ill Children (OPTIC)

Cardiac DiseaseCritically IllChildren, Adult
Duke University2,000 enrolled1 locationNCT05055830
Recruiting
Not Applicable

Parasternal Intercostal Muscle Thickening as an Additive Weaning Criterion

Critically Ill
Cairo University200 enrolled1 locationNCT07143695
Recruiting
Not Applicable

Ultrasound and MRI Measurement of Quadriceps Femoris Muscle in Critically Ill Children

Quadriceps Femoris Measurement as a Surrogate of Muscle Mass Assessment in Critically Ill Children
Hospices Civils de Lyon35 enrolled1 locationNCT05108441
Recruiting

Disease Severity, Mortality Risk, and Muscle Function in Intensive Care Unit Patients

Critically Ill Patients
Istinye University45 enrolled1 locationNCT07124442