Critically Ill Clinical Trials

58 recruitingLast updated: June 18, 2026

There are 58 actively recruiting critically ill clinical trials across 31 countries. Studies span Not Applicable, Phase 3, Phase 2, Phase 1, Phase 4. Top locations include Kingston, Ontario, Canada, London, Ontario, Canada, Cairo, Egypt. Updated daily from ClinicalTrials.gov.


Critically Ill Trials at a Glance

58 actively recruiting trials for critically ill are listed on ClinicalTrialsFinder across 6 cities in 31 countries. The largest study group is Not Applicable with 14 trials, with the heaviest enrollment activity in Kingston, London, and Cairo. Lead sponsors running critically ill studies include Intensive Care Unit, John Hunter Hospital, Ain Shams University, and Assistance Publique - Hôpitaux de Paris.

Browse critically ill trials by phase

Treatments under study

About Critically Ill Clinical Trials

Looking for clinical trials for Critically Ill? There are currently 16 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Critically Ill trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Critically Ill clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 58 trials

Recruiting
Phase 3

Comparative Efficacy and Safety of Propofol-Ketamine Combination Versus Propofol Monotherapy in Geriatric Patients Under Invasive Ventilation

PneumoniaSeptic ShockThe Critically Ill Patient is Requiring Intubation
Helwan University41 enrolled2 locationsNCT07530146
Recruiting

Factor Associated With Mortality in the ICU

Intensive Care MedicineMortalityCritically Ill+3 more
Hospital Departamental de Villavicencio1,000 enrolled1 locationNCT07249749
Recruiting

Heterogeneity of Critical Illness: a Cohort Study

Organ Failure, MultipleCritically Ill
University Medical Center Groningen5,000 enrolled1 locationNCT04502511
Recruiting

Immunosuppression and Intensive Care Unit-acquired Multidrug-resistant Bacteria

Critically Ill Patients
University Hospital, Lille1,000 enrolled1 locationNCT06652126
Recruiting
Not Applicable

Reliability of Minimally Trained Operator's Velocity-Time Integral Measurement Guided by Artificial Intelligence VTI

Critically Ill PatientsVelocity-time Integral MeasurementTissue Hypoperfusion
Assistance Publique - Hôpitaux de Paris100 enrolled3 locationsNCT06486467
Recruiting
Not Applicable

The Effect of Muscle Stimulation and Amino Acid Intake on Protein Metabolism During Critical Illness

Muscle Wasting in Critically Ill
Wageningen University30 enrolled1 locationNCT07430969
Recruiting

Induction Agent Choice With Early Mortality and Prognostic Outcomes in Critically Ill Patients

OxygenationAirway ManagementCritically Ill+3 more
Zeliha Alicikus4 enrolled1 locationNCT07222007
Recruiting

Blood Sampling Pre- and Post-Propofol Administration to Characterize the Blood Proteome Using Different Research Assays

Critically Ill Surgical Patients
National Institutes of Health Clinical Center (CC)10 enrolled1 locationNCT07295795
Recruiting

Rezafungin Peritoneal Diffusion for Intra-abdominal Candidiasis

abdominal surgery patientsCandidaCritically Ill Intensive Care Unit Patients+1 more
Central Hospital, Nancy, France20 enrolled1 locationNCT07093203
Recruiting

Epidemiology and Processes of Care for Renal Replacement Therapy in Acute Kidney Injury in Latin America

renal replacement therapyAcute Kidney InjuryRenal Replacement Therapy for Acute Kidney Injury in ICU+3 more
University of Alabama at Birmingham1,000 enrolled15 locationsNCT07262320
Recruiting
Phase 4

Effects of Donor-recipient Sex-matched Blood Transfusion on Patient Outcomes

CardiovascularRed Blood Cell TransfusionsSex Differences+3 more
Michelle Zeller11,082 enrolled8 locationsNCT06840756
Recruiting
Not Applicable

Accuracy and Safety of the Syai Tag System for Continuous Glucose Monitoring in Intensive Internal Care Unit

Diabetes MellitusSepsisCritically Ill Intensive Care Unit Patients+1 more
University Medical Centre Maribor100 enrolled1 locationNCT07448805
Recruiting
Phase 3

Advancing Brain Outcomes in Pediatric Critically Ill Patients Sedated With Volatile AnEsthestic Agents

Intensive Care Units, PediatricAnesthetics, InhalationMechanically Ventilated, Critically Ill Children
Sunnybrook Health Sciences Centre60 enrolled3 locationsNCT05867472
Recruiting
Not Applicable

Feasibility of End-tidal Oxygen Concentration Monitoring During Preoxygenation for Intubation in the Intensive Care Unit.

Critically Ill
Centre Hospitalier Régional d'Orléans30 enrolled1 locationNCT05409573
Recruiting

SOFA-2 Score in Turkish ICUs

Critically Ill Intensive Care Unit PatientsIntensive Care Unit Patients
Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital5,200 enrolled1 locationNCT07338240
Recruiting

Clinical Characteristics and Epidemiology of Chronic Critically Ill Patients in China

Chronic Critically Ill
West China Hospital459 enrolled1 locationNCT07372742
Recruiting

Analgesia Nociception Index to Explore Autonomic Nervous System in Patients With Continuous Renal Replacement Therapy

renal replacement therapyCritically Ill
Hospices Civils de Lyon30 enrolled1 locationNCT06285162
Recruiting
Not Applicable

Stepwise Enteral Nutritional Algorithm and Patient Outcomes in Pediatric Intensive Care Units

enteral nutritionEnteral Nutrition FeedingEnteral Nutrition Intolerance in Critically Ill Patients
Ain Shams University80 enrolled1 locationNCT07307027
Recruiting
Not Applicable

Quality Improvement Intervention for a Safe Antimicrobial Use Reduction in Critically Ill Patients

Antimicrobial StewardshipInfectionCritically Ill Intensive Care Unit Patients
Hospital Sirio-Libanes9,000 enrolled9 locationsNCT07093450
Recruiting

MuScle WastIng and DysphaGia iN CriticAlly IlL Patients (SIGNAL)

Swallowing DisordersCritical IllnessDysphagia+1 more
Barts & The London NHS Trust160 enrolled1 locationNCT07076524