RecruitingNot ApplicableNCT06288464

Enteral Feeding of Fibre to Improve Microbiota

Does Distal Enteral Feeding of Fibre Positively Affect the Microflora in the Distal Limb of Loop Ileostomy Patients?

Sponsor

Lancashire Teaching Hospitals NHS Foundation Trust

Enrollment

15 participants

Start Date

Jan 9, 2023

Study Type

INTERVENTIONAL

Conditions

Colon Disease Bowel Dysfunction Ileum--Diseases

Summary

Following surgical removal of diseased bowel, patients often require a temporary redirection of bowel contents to a stoma, to allow healing prior to re-joining of the remaining bowel at a later date. Some patients may experience complications, either during or after reversal surgery, and this may be due to changes in the 'friendly' bacteria that live in our bowels. Previous research shows that the distal section of bowel that is non-functioning undergoes tissue-wasting and the 'friendly' bacteria that help our digestion die. Data shows that patients that have a reduction in their microflora are more likely to experience side effects. This study investigates a method of replenishing the microflora prior to surgery.

Eligibility

Min Age: 18 Years

Inclusion Criteria2

Any individual that has been identified for distal (stoma) feeding that is able to understand verbal and written English to provide informed consent.
Participants must be undergoing ileostomy or colostomy reversal surgery.

Exclusion Criteria2

Not undergoing ileostomy or colostomy reversal.
Persons who might not adequately understand verbal explanations or written information given in English

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Interventions

DIETARY_SUPPLEMENTSoluble Fibre

Patients will be assigned to stoma feeding by the Colorectal Surgeon, which will be managed by the stoma nurses for the duration, approximately 4 weeks, of feeding. For the final 7-14 days (minimum 7 days) of feeding, 10g of soluble fibre will be added to 100ml of Ensure™ (or equivalent liquid nutrient feed) before instillation into the stoma on a daily basis. The soluble fibre will be provided in 10g portions and should be added to the newly-opened bottle of ensure and shaken to mix well.