TDCS Interventions for Subthreshold Depressive Symptoms in Young Individuals.
Transcranial Direct Current Stimulation Interventions for Subthreshold Depressive Symptoms in Young Individuals.
Guangzhou Psychiatric Hospital
150 participants
Nov 1, 2023
INTERVENTIONAL
Conditions
Summary
The purpose of this study is to assess the mechanisms of the effect of transcranial direct current stimulation (tDCS) in alleviating subthreshold depressive symptoms in young individuals, and individualized outcome prediction is carried out.
Eligibility
Inclusion Criteria6
- \) Be between the ages of 12-25;
- \) is right-handed on the Edinburgh Handedness Inventory;
- \) 2-4 of the 9 depressive symptoms defined by the American Diagnostic and Statistical Manual of Diseases, Fifth Edition (DSM-5), lasting more than 1 week; or more than 5 depressive symptoms lasting more than 1 week but less than 2 weeks (i.e., not meeting criteria for a major depressive episode) (by DSM-5 Clinical Semi-Definitive Interview (K-SADS-PL) (Gilbody et al., 2017, JAMA);
- \) Hamilton Depression Scale (HAMD-24) 24 points≥ 8 points, \< 24 points;
- \) Gender is not limited;
- \) Subjects and their families voluntarily participate and sign the informed consent form.
Exclusion Criteria7
- \) Individuals with the following diagnoses according to DSM-5: psychiatric disorders due to organic diseases, substance-related and addictive disorders, neurodevelopmental disorders, schizophrenia spectrum and other psychotic disorders, bipolar disorder (assessed by K-SADS-PL);
- \) Have two or more DSM-V-defined manic symptoms for 4 days but do not meet the criteria for hypomania or meet the DSM-V defined criteria for hypomanic symptoms for only 2-3 days;
- \) Severe or unstable physical illness;
- \) have a moderate or higher risk of suicide (as assessed by the Columbia Suicide Severity Scale);
- \) Received transcranial direct current stimulation in the past three months (continuous intervention time: \>2 weeks);
- \) Contraindications to transcranial direct current stimulation, such as brain implants, personal or family history of epilepsy;
- \) Magnetic resonance scanning is contraindicated, such as in vivo metal implants.
Interventions
The current is 2mA, duration is 1200s, fade in 30s, fade out 30s, anode is on the F3, cathode is on the FP2.
The current is 2mA, duration is 1200s, fade in 30s, fade out 30s, anode is on the F6, cathode is on the FP1.
The current only persist in the fisrt 30s, duration is 1200s, fade in 30s, fade out 30s, anode is on the F3/F6, cathode is on the FP2/1.
Locations(1)
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NCT06294184