RecruitingNot ApplicableNCT06864715

Behavioral Activation for the PreVention of Post-strokE Depression in LoW-incomE Older Stroke Survivors

Behavioral Activation for the PreVention of Post-strokE Depression in LoW-incomE Older Stroke Survivors (LIVE-WEL)

Sponsor

The University of Texas Health Science Center, Houston

Enrollment

350 participants

Start Date

Apr 10, 2026

Study Type

INTERVENTIONAL

Conditions

Post-stroke Depression Subthreshold Depression

Summary

The overall objective of the project is to determine the effectiveness of tele-delivered behavioral activation (BA) by trained lay counselors (Tele-BA-S) to prevent Post-stroke depression (PSD) in low-income, older stroke survivors with subthreshold depression (SD).

Eligibility

Min Age: 55 Years

Inclusion Criteria6

Enrollment within 3-months +2 weeks of a first-time ischemic or hemorrhagic stroke
-item HDRS score < 15 indicating subthreshold depression defined as the absence of depressive symptoms or presence of mild symptoms of depression
Single person income less than or equal to $45,000
Residing in a community residence
Ability to speak and read in English or Spanish
Mini-MoCA score > or equal to 11

Exclusion Criteria9

Stroke event unrelated to vascular risk factors (e.g., drug use) or transient ischemic attack
-item HDRS score > or equal to 15 indicating moderate to severe depression
Actively participating in psychotherapy
high suicide risk or severe psychiatric illness (e.g., bipolar disorder and active psychosis) and/or actively taking antipsychotics
Diagnosed dementia and/or currently taking cognitive enhancers, amyloid-targeting medications, or orexin receptor antagonists
Patient Health Questionnaire 9 score > or equal to 10 and/or answers positive to Q9
Diagnosed aphasia and/or severe cognitive impairments
high-risk alcohol or drug misuse
receiving medications for mood disorders and a change in dose or type within the last 4 weeks

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Interventions

BEHAVIORALTele-delivered Behavioral Activation by lay counselors after Stroke (Tele-BA-S)

The Tele-BA-S intervention will comprise 5 weekly video-conferenced BA sessions delivered by trained lay counselors, homework, and 2 monthly follow-up booster calls. Participants will receive the standard hospital discharge post-stroke educational packet and a scheduled follow-up appointment with a stroke practitioner to evaluate patients at 7-14 days and 3 months ±14 days, according to current standard of care. They will be seen over video or in-person, according to their preference and capabilities.

BEHAVIORALTreatment as Usual

Participants will receive the standard hospital discharge post-stroke educational packet and a scheduled follow-up appointment with a stroke practitioner to evaluate patients at 7-14 days and 3 months ±14 days, according to current standard of care. They will be seen over video or in-person, according to their preference and capabilities.